1418029-14-7

Basic information

• Product Name: 1-(4-methylphenyl)-3-trifluoroacetyl-1H-pyrrole
• CAS NO: 1418029-14-7
• Molecular Weight: 253.224
• Mol File: 1418029-14-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-methylphenyl)-3-trifluoroacetyl-1H-pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methylphenyl)-3-trifluoroacetyl-1H-pyrrole(1418029-14-7)
• EPA Substance Registry System: 1-(4-methylphenyl)-3-trifluoroacetyl-1H-pyrrole(1418029-14-7)

Safety Data

• Hazardous Substances Data: 1418029-14-7(Hazardous Substances Data)

Upstream product

• 1418029-23-8 C₁₃H₁₄F₃NO₂ 
• 109317-75-1 4-trifluoroacetyl-2,3-dihydrofuran 
• 106-49-0 p-toluidine 

Relevant articles and documents

Improved one-pot synthesis of 1-aryl-3-trifluoroacetyl-1H-pyrroles under Swern oxidation

This study describes an improved one-pot, four-step synthesis of a new series of 1-aryl-3-trifluoroacetyl pyrroles from the reaction of 3-trifluoroacetyl-4,5-dihydrofuran with arylamines, giving 1,1,1-trifluoro-3-(2- hydroxyethyl)-4-arylamino-3-buten-2-ones, which were directly submitted to Swern oxidation to furnish 1,1,1-trifluoro-3-(2-ethanal)-4-arylamino-3-buten-2-ones. Subsequent intramolecular cyclization of the corresponding enaminoaldehydes followed by aromatization rendered the title compounds in a 30 to 56% overall yield.