1418031-60-3

Upstream product

• 1418031-57-8 C₂₅H₄₀O₆Si 
• 1418031-59-0 C₃₀H₄₈O₇Si 
• 1418031-58-9 C₂₂H₃₄O₆Si 
• 72261-44-0 1,2-O-isopropylidene-3-O-benzyl-4-C-(hydroxymethyl)-β-L-threo-pento-1,4-furanose 
• 23558-05-6 3-O-benzyl-1,2-O-isopropylidene-1,5-D-xylo-dialdofuranose 
• 591727-19-4 1-2,5-6 di-O-isopropylidene 3-O-benzyl α(D)gluco-pentoaldofuranose 
• 1027758-99-1 3-O-benzyl-5-O-[tert-butyl(dimethyl)silyl]-4-(hydroxymethyl)-1,2-O-(1-methylethylidene)-β-L-arabinofuranose 

Downstream Products

• 1418031-61-4 C₂₄H₃₂O₇ 

Relevant academic research and scientific papers

TRICYCLIC NUCLEIC ACID ANALOGS

The present disclosure provides tricyclic nucleosides and oligomeric compounds prepared therefrom. The tricyclic nucleosides each have a tricyclic ribosyl sugar moiety wherein a bridge between the 2' and 4' ribosyl ring carbon atoms further comprises a fused carbocyclic or heterocyclic ring. The tricyclic nucleosides are expected to be useful for enhancing properties of oligomeric compounds including for example binding affinity and nuclease resistance.

Structure-based design of a highly constrained nucleic acid analogue: Improved duplex stabilization by restricting sugar pucker and torsion angle γ

Dual conformational restriction: A new, highly constrained modification of the α-L-locked nucleic acid (α-L-LNA) scaffold that locks the sugar furanose ring in an N-type configuration and also restricts rotation around torsion angle γ was synthesized (see scheme). This new modification increases the thermostability of an oligonucleotide duplex compared to using a single mode of constraint alone. Copyright