141805-71-2Relevant academic research and scientific papers
INHIBITORS OF C-MET AND USES THEREOF
-
Page/Page column 81; Figure 5, (2008/06/13)
The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment o
Biologically Active Metabolites of Fungi, I.-Isolation, Synthesis, and Biological Activity of Coniothyriomycin as well as Bioassay of Analogous Open-Chain Imides
Krohn, Karsten,Franke, Claudia,Jones, Peter G.,Aust, Hans-Juergen,Draeger, Sigfried,Schulz, Barbara
, p. 789 - 798 (2007/10/02)
The mixed open-chain imide N-(3-chloro-4-hydroxyphenylacetyl)fumarate (1), named coniothyriomycin, was isolated as a metabolite of the fungus Coniothyrium.The natural product 1 and the analoguos imides 13-15 and 22-24 have been synthesized by base-catalyzed condensation of the imidates 12a-f with acid chlorides 6a-c or the mixed anhydride 21.The compounds 1 and 13-15 were shown to posess remarkable fungicidal and herbicidal activities in short-termed tests. Key Words: Fungal metabolites / Imides, open-chain / Fungicidal activity / Coniothriomycin
Synthesis and Antiinflammatory Activity of 2,2'-Diaminobiphenyl Derivatives
Calcinari, Romano,Case, Nadia,Guerrato, Alfredo,Milanino, Roberto,Passarella, Elda,et al.
, p. 632 - 634 (2007/10/02)
A series of 2,2'-diaminobiphenyl derivatives was prepared and tested for antiinflammatory activity.Several compounds showed antiinflammatory activity, particularly 2-amino>-2'-amino>biphenyl (4), which als
