141807-58-1Relevant articles and documents
Synthesis of β-CIT-BAT, a potential technetium-99m imaging ligand for dopamine transporter
Tamagnan,Tamagnan, Gilles,Gao,Gao, Yigong,Baldwin,Baldwin, Ronald M.,Zoghbi,Zoghbi, Sami S.,Neumeyer,Neumeyer, John L.
, p. 4353 - 4356 (1996)
The synthesis of an N2S2 conjugated BAT phenyltropane ligand is described. This agent can be further used to incorporate technetium-99m to form a neutral complex for SPECT imaging of the dopamine transporter.
Synthesis and amine transporter affinities of novel phenyltropane derivatives as potential positron emission tomography (PET) imaging agents
Peng, Xuemei,Zhang, Ao,Kula, Nora S.,Baldessarini, Ross J.,Neumeyer, John L.
, p. 5635 - 5639 (2007/10/03)
A series of novel fluoroalkyl-containing tropane derivatives were synthesized from cocaine. The binding affinities for DAT, SERT, and NET were determined via competitive binding assays. A series of novel fluoroalkyl-containing tropane derivatives (6-8, 10
Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: Potential positron emission tomography (PET) imaging agents for the dopamine transporter
Gu, Xiao-Hui,Zong, Rushi,Kula, Nora S.,Baldessarini, Ross J.,Neumeyer, John L.
, p. 3049 - 3053 (2007/10/03)
A series of novel fluoroalkyl-containing tropane derivatives was synthesized, and their binding affinities for the dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET) were determined via competitive binding assays. Among these derivatives, the fluoropropyl ester of β-CIT (19), the fluoroethyl ester of β-CIT (20), the N-fluoropropyl derivative of β-CBT (12), and the fluoropropyl ester of β-CMT (18) displayed higher affinity and greater selectivity for the DAT versus SERT and NET than FP-CIT, which indicates that they are attractive candidates for the development of 18F-labeled PET imaging agents for the DAT.