141807-97-8Relevant academic research and scientific papers
Xanthine derivatives
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, (2008/06/13)
The present invention relates to novel xanthine derivatives of the formula (I) which are selectively antagonistic to an adenosine A 2 receptor, and pharmaceutically acceptable salts thereof. Formula (I): STR1 In the formula, R 1 and R 2 are the same or di
Adenosine A(2A) antagonists with potent anti-cataleptic activity
Shimada, Junichi,Koike, Nobuaki,Nonaka, Hiromi,Shiozaki, Shizuo,Yanagawa, Koji,Kanda, Tomoyuki,Kobayashi, Hiroyuki,Ichimura, Michio,Nakamura, Joji,Kase, Hiroshi,Suzuki, Fumio
, p. 2349 - 2352 (2007/10/03)
Structure-activity relationships of 8-styrylxanthines for in vivo adenosine A(2A) antagonism were explored. Diethyl substitution both at the 1- and S-position was found to dramatically potentiate the anti-cataleptic activity.
