141811-50-9

Basic information

• Product Name: Thiophene, 3-bromo-2-ethenyl-
• CAS NO: 141811-50-9
• Molecular Formula: C6H5BrS
• Molecular Weight: 189.076
• Mol File: 141811-50-9.mol

Chemical Properties

• CAS DataBase Reference: Thiophene, 3-bromo-2-ethenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiophene, 3-bromo-2-ethenyl-(141811-50-9)
• EPA Substance Registry System: Thiophene, 3-bromo-2-ethenyl-(141811-50-9)

Safety Data

• Hazardous Substances Data: 141811-50-9(Hazardous Substances Data)

Upstream product

• 930-96-1 3-bromo-2-thiophenecarboxaldehyde 
• 1779-49-3 Methyltriphenylphosphonium bromide 

Downstream Products

• 91319-38-9 2-phenylthieno<3,2-c><1,2,4>triazolo<1,2-a>pyridazine-1,3-dione 

Relevant articles and documents

Enantioselective Construction of Spiro Quaternary Carbon Stereocenters via Pd-Catalyzed Intramolecular α-Arylation

We herein report the development of a sterically hindered and electron-rich P-chiral monophosphorus biaryl ligand that has enabled a general and efficient enantioselective intramolecular α-arylation, providing access to a wide series of [4.4], [4.5], and [4.6]-spirocycles with chiral benzylic quaternary carbons in high yields with good to excellent enantioselectivities. A pronounced water effect on enantioselectivity is observed.

Unlocking Mizoroki–Heck-Type Reactions of Aryl Cyanides Using Transfer Hydrocyanation as a Turnover-Enabling Step

A new transfer hydrofunctionalization strategy to turnover H-MII-X complexes has enabled both intra- and intermolecular Mizoroki–Heck (MH)-type reactions of aryl cyanides that are challenging to realize under traditional, basic conditions. Initially, a cascade carbonickelation/MH reaction of 2-cyanostyrenes was achieved using a key alkyne transfer hydrocyanation step. Mechanistic experiments supported the proposed catalytic cycle, including the turnover-enabling transfer hydrocyanation step. The reactivity was then extended to the intermolecular MH reaction of benzonitriles and styrenes.