1418136-40-9Relevant academic research and scientific papers
The facile synthesis of 2-bromoindoles via Cs2CO 3-promoted intramolecular cyclization of 2-(gem-dibromovinyl)anilines under transition-metal-free conditions
Li, Pinhua,Ji, Yong,Chen, Wei,Zhang, Xiuli,Wang, Lei
, p. 73 - 78 (2013/03/29)
2-Bromoindoles were readily prepared through a facile Cs2CO 3-promoted intramolecular cyclization of 2-(gem-bromovinyl)-N- methylsulfonylanilines in excellent yields under transition-metal-free conditions. This methodology could be extended to the synthesis of corresponding 2-chloroindoles. The reaction mechanism suggested that cyclization occurs through a key intermediate, phenylethynyl bromide, followed by cyclization in one-pot. The Royal Society of Chemistry.
