1418296-95-3

Upstream product

• 473917-15-6 3-fluoro-4-(trifluoromethoxy)benzaldehyde 
• 1418296-87-3 2-({fluoro[5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl]methyl}sulphonyl)-1,3-benzothiazole 
• 180518-73-4 [5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl]methanol 
• 1418296-88-4 ethyl 5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carboxylate 
• 4027-57-0 ethyl 5-methyl-1H-pyrazole-3-carboxylate 
• 110-87-2 3,4-dihydro-2H-pyran 
• 1418296-91-9 2-({[5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl]methyl}sulphonyl)-1,3-benzothiazole 
• 1418296-90-8 2-({[5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl]methyl}sulphanyl)-1,3-benzothiazole 
• 1418296-89-5 [5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl]methylmethane-sulphonate 

Downstream Products

• 1418296-94-2 3-{(Z)-1-fluoro-2-[3-fluoro-4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazole 
• 1418296-28-2 2-chloro-5-[(3-{(Z)-1-fluoro-2-[3-fluoro-4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]pyridine 

Relevant academic research and scientific papers

3-(Fluorovinyl)pyrazoles and their use

The present application relates to novel 3-(fluorovinyl)pyrazole derivatives, to processes for their preparation, to their use for treatment and/or prevention of diseases and to their use for the preparation of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be carried out as monotherapy or also in combination with other medicaments or further therapeutic measures.