14183-51-8

Basic information

• Product Name: 2H-1,4-BENZOXAZINE-3(4H)-THIONE
• Synonyms: 2H-1,4-BENZOXAZINE-3(4H)-THIONE;BUTTPARK 10\09-20;3,4-Dihydro-3-thioxo-2H-1,4-benzoxazine;4H-1,4-benzoxazine-3-thione
• CAS NO: 14183-51-8
• Molecular Formula: C₈H₇NOS
• Molecular Weight: 165.21
• Mol File: 14183-51-8.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2H-1,4-BENZOXAZINE-3(4H)-THIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1,4-BENZOXAZINE-3(4H)-THIONE(14183-51-8)
• EPA Substance Registry System: 2H-1,4-BENZOXAZINE-3(4H)-THIONE(14183-51-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 14183-51-8(Hazardous Substances Data)

Upstream product

• 5466-88-6 3,4-dihydro-3-oxo-2H-1,4-benzoxazine 
• 90-04-0 2-methoxy-phenylamine 
• 95-55-6 2-amino-phenol 

Downstream Products

• 14598-40-4 4-amino-benzoic acid (4H-benzo[1,4]oxazin-3-ylidene)-hydrazide 
• 21744-81-0 (2H-benz[1,4]oxazin-3-yl)-phenyl-amine 
• 96780-78-8 C₁₅H₁₄N₄OS 
• 1586007-24-0 4-((1-(4-chlorophenyl)-1,2,3-triazol-4-yl)methyl)-2H-benzo[b][1,4]oxazine-3(4H)-thione 
• 1432501-01-3 4-((1-(2-fluorophenyl)-1,2,3-triazol-4-yl)methyl)-2H-benzo[b][1,4]oxazine-3(4H)-thione 
• 1586007-23-9 4-((1-p-tolyl-1,2,3-triazol-4-yl)methyl)-2H-benzo[b][1,4]oxazine-3(4H)-thione 
• 1432501-04-6 4-((1-(2-chlorophenyl)-1,2,3-triazol-4-yl)methyl)-2H-benzo[b][1,4]oxazine-3(4H)-thione 
• 1432501-03-5 4-((1-o-tolyl-1,2,3-triazol-4-yl)methyl)-2H-benzo[b][1,4]oxazine-3(4H)-thione 
• 14598-38-0 4H-benzo[1,4]oxazin-3-one O-benzyl-oxime 
• 96753-85-4 2,4-dihydro-6,8-dinitro-1-oxo<1,2,4>triazolo<3,4-c><1,4>benzoxazine 
• 78959-41-8 ethoxyformic acid 2-(2H-1,4-benzoxazin-3-yl)hydrazide 
• 78959-38-3 5-nitro-2-furoic acid 2-(2H-1,4-benzoxazin-3-yl)hydrazide 
• 78959-34-9 p-ethoxybenzoic acid 2-(2H-1,4-benzoxazin-3-yl)hydrazide 
• 78959-32-7 o-hydroxybenzoic acid 2-(2H-1,4-benzoxazin-3-yl)hydrazide 

Relevant articles and documents

A PTC assisted thionation: Synthesis of 2H-1,4-benzoxazine-3(4H)-thiones & 2H-1,4-benzothiazine-3(4H)-thiones

A facile method for the conversion of 2H-1,4-benzoxa/thiazine-3(4H)-ones to their respective thiones under PTC (P2S5/K2CO3/TEBA) conditions is reported.

Preparation method of benzoxazine-and-pyrazol-calcium complex with anti-platelet aggregation activity

The invention discloses a preparation method of a benzoxazine-and-pyrazol-calcium complex with anti-platelet aggregation activity, and belongs to the technical field of pharmaceutical synthesis. The key point of the preparation method is as shown in the specification. Compared with the prior art, the preparation method has the beneficial effects that the synthesis method is simple, and the molecular structure is novel; furthermore, the anti-platelet aggregation effect of the synthesized compound is equivalent to that of ticlopidine, so that the compound is desired to be further popularized and applied.

1. 4 - benzoxazine - 1, 2, 3 - triazole class compound and its synthetic method and application

The invention discloses a 1,4-benzoxazine-1,2,3-triazole compound as well as a synthesis method and application thereof. The synthesis method comprises the following steps: fetching the raw materials, namely 1,4-benzoxazine thione and an azide compound, putting the two raw materials into a mixed solvent, and reacting in the presence of an inert gas and a catalyst, thereby obtaining a target product. The 1,4-benzoxazine-1,2,3-triazole compound can be applied to the prevention of animal/plant diseases caused by bacteria and the prevention of human leukemia cell lines K562 and breast cancer cells MCF-7. According to the 1,4-benzoxazine-1,2,3-triazole compound disclosed by the invention, the 1,2,3-triazole with various bioactivities is introduced into 1,4-benzoxazine, and the synthesized compound has excellent bioactivity, can be applied to the prevention of animal/plant diseases and also has tremendous potential in the field of anti-cancer drug development.