141841-67-0Relevant articles and documents
Three 2-(methysulfanyl)nicotinamides
Gomes, Ligia R.,Low, John Nicolson,Wardell, James L.,Pinheiro, Alessandra C.,De Mendon?a, Thais C. N.,De Souza, Marcus V. N.
, p. 293 - 298 (2013)
The molecular conformations of three N-alkyl-2-(methylsulfanyl)nicotinamide derivatives, namely N-cyclohexyl-2-(methylsulfanyl)nicotinamide, C 13H18N2OS, (I), N-isopropyl-2-(methylsulfanyl) nicotinamide, C10H14N2OS, (II), in which there are two molecules in the asymmetric unit which were chosen to form a hydrogen-bonded pair, and N-(2-hydroxyethyl)-2-(methylsulfanyl)nicotinamide dihydrate, C9H12N2O2S·2H 2O, (III), are compared with those of four unsubstituted N-alkylnicotinamide compounds. The substituted compounds show a higher degree of torsion of the pyridine ring with respect to the amide group than do the unsubstituted compounds, with dihedral angles in the range 40-60° for the former and 20-35° for the latter. In (I) and (II), the supramolecular structure is defined by amide-N to carbonyl-O chains. In (III), the nicotinamide molecules are linked by hydrogen bonds to two water molecules resulting in two linked chains of rings which form the three-dimensional network. Copyright
Synthesis and antifungal activity of nicotinamide derivatives as succinate dehydrogenase inhibitors
Ye, Yong-Hao,Ma, Liang,Dai, Zhi-Cheng,Xiao, Yu,Zhang, Ying-Ying,Li, Dong-Dong,Wang, Jian-Xin,Zhu, Hai-Liang
, p. 4063 - 4071 (2014/05/20)
Thirty-eight nicotinamide derivatives were designed and synthesized as potential succinate dehydrogenase inhibitors (SDHI) and precisely characterized by 1H NMR, ESI-MS, and elemental analysis. The compounds were evaluated against two phytopath
