141845-82-1 Usage
Asthma medication
Ciclesonide is a new inhaled glucocorticoid drug for treating asthma,it belongs to adrenocorticotropic hormone drugs, similar drugs also include beclomethasone dipropionate, budesonide, fluticasone propionate, the product is administrated in a non-active form ,it can be activated by endogenous esterases in the airway on the spot , it becomes into an active ingredient when it reaches the target organ-the lung; once it is activated, it shows a high topical anti-inflammatory activity.
Ciclesonide is successfully developed by the pharmaceutical company Altana, it was listed in January 2005 for the first time in the UK, it is currently available in Germany, Ireland, it is used for the treatment of adults with all levels of persistent severe asthma, one administration per day , a dose of 160μg or 80μg. For patients with severe asthma attack facing the risk of asthma, if the condition can not be controlled and strong anti-inflammatory drugs are required , the dose of this product be increased to 160μg.
In clinical trail phase III of severe patients with persistent asthma, ciclesonide has new release and distribution properties,it can reduce the local and systemic adverse reactions, and it can maintain high anti-asthma activity, it can significantly low the need on oral corticosteroids (OCS) in patients to maintain or improve effects of asthma control. Accordingly, it is an appropriate OCS saving therapy.
Side Effects
Ciclesonide becomes effective faster than budesonide,its systemic side effects are lower than the fluticasone propionate and budesonide, even though the highest doses of 160μg is used, plasma glucocorticoid inhibition is also higher than other corticosteroids inhalants (if high plasma corticosterone hormone levels are high ,the systemic side effects is high).
Local side effects comparison table is as follows:
Side effects of this product fluticasone propionate budesonide
Dysphonia (hoarseness) 1.6% 4% 1%-8%-6%
Sore throat 1.9% 10%-14% 5%-10%
Thrush 0.2%-5% 2% 2%-4%
The above information is edited by the lookchem of Tian Ye.
Uses
Treatment of asthma
as prophylactic therapy in adults and adolescents.
Check Digit Verification of cas no
The CAS Registry Mumber 141845-82-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,8,4 and 5 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 141845-82:
(8*1)+(7*4)+(6*1)+(5*8)+(4*4)+(3*5)+(2*8)+(1*2)=131
131 % 10 = 1
So 141845-82-1 is a valid CAS Registry Number.
InChI:InChI=1/C32H44O7/c1-18(2)28(36)37-17-25(35)32-26(38-29(39-32)19-8-6-5-7-9-19)15-23-22-11-10-20-14-21(33)12-13-30(20,3)27(22)24(34)16-31(23,32)4/h12-14,18-19,22-24,26-27,29,34H,5-11,15-17H2,1-4H3/t22-,23-,24-,26+,27+,29+,30-,31-,32+/m0/s1
141845-82-1Relevant articles and documents
Preparation method of ciclesonide
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, (2021/08/07)
The invention discloses a preparation method of ciclesonide. The preparation method comprises the following steps: aldolization reaction, primary purification, hydrolysis reaction, esterification reaction and secondary purification. Aldolization reaction:
Preparation method of ciclesonide
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, (2018/03/24)
The invention provides a new synthetic route for preparation of ciclesonide. The method comprises the steps that used raw materials are cheaper and available, the reaction raw materials are protectedafter hydroxylation, selective oxidation of a five-membered ring double bond is then performed, then, a six-membered ring double bond bromination is conducted, bromine atom is removed by reduction, acarbonyl group and a hydroxyl protecting group are removed, then, an oxidized dihydroxyl group is protected, the six-membered ring double bond is then epoxidized and reacts with cyclohexanecarboxaldehyde and isobutyryl chloride in turn to obtain a ciclesonide product. A reaction process is easy to operate, yield is higher in each step, purity of the obtained product is also higher, generation of by-products is effectively avoided, production cost is reduced, and the new synthetic route for the preparation of the ciclesonide is advantageous to industrial production.
NOVEL PROCESS FOR PREPARATION OF GLUCOCORTICOID STEROIDS
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, (2016/08/23)
The present invention discloses a process for the preparation of 16, 17-acetals of pregnane derivatives having formula (I) wherein each substituent is independently selected from; R1 is H or CH3; R2 is C1-C6 linear or branched alkyl, alkynyl group or cycloalkyl group; aryl or heteroaryl group; or R1 and R2 combine to form saturated, unsaturated C3-C6 cyclic or heterocyclic ring; R3 and R4 are same or different and each independently represents H or halogen; R5 is -OH or –OCOR wherein R represents H or C1-C6 linear, branched or cyclic alkyl group that may be substituted.
