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141845-82-1

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ac1miwnr CAS:141845-82-1
Cas No: 141845-82-1
USD $ 0.32-0.98 / Gram 1 Gram 1 Metric Ton/Day WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
Factory Supply Ciclesonide
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No Data 100 Gram 4000 Metric Ton/Day Ality Chemical Corporation Contact Supplier
High Purity Ciclesonide Powder for Antiasthmatic CAS141845-82-1 with Best Price
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AC1MIWNR CAS 141845-82-1
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CAS NO.141845-82-1 Ciclesonide
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No Data No Data No Data Shandong Hanjiang Chemical Co., Ltd. Contact Supplier
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141845-82-1 Usage

Uses

Treatment of asthma as prophylactic therapy in adults and adolescents.

Asthma medication

Ciclesonide is a new inhaled glucocorticoid drug for treating asthma,it belongs to adrenocorticotropic hormone drugs, similar drugs also include beclomethasone dipropionate, budesonide, fluticasone propionate, the product is administrated in a non-active form ,it can be activated by endogenous esterases in the airway on the spot , it becomes into an active ingredient when it reaches the target organ-the lung; once it is activated, it shows a high topical anti-inflammatory activity.
Ciclesonide is successfully developed by the pharmaceutical company Altana, it was listed in January 2005 for the first time in the UK, it is currently available in Germany, Ireland, it is used for the treatment of adults with all levels of persistent severe asthma, one administration per day , a dose of 160μg or 80μg. For patients with severe asthma attack facing the risk of asthma, if the condition can not be controlled and strong anti-inflammatory drugs are required , the dose of this product be increased to 160μg.
In clinical trail phase III of severe patients with persistent asthma, ciclesonide has new release and distribution properties,it can reduce the local and systemic adverse reactions, and it can maintain high anti-asthma activity, it can significantly low the need on oral corticosteroids (OCS) in patients to maintain or improve effects of asthma control. Accordingly, it is an appropriate OCS saving therapy.

Brand name

Alvesco (Dynamit Nobel GmbH).

Side Effects

Ciclesonide becomes effective faster than budesonide,its systemic side effects are lower than the fluticasone propionate and budesonide, even though the highest doses of 160μg is used, plasma glucocorticoid inhibition is also higher than other corticosteroids inhalants (if high plasma corticosterone hormone levels are high ,the systemic side effects is high).
Local side effects comparison table is as follows:
Side effects of this product fluticasone propionate budesonide
Dysphonia (hoarseness) 1.6% 4% 1%-8%-6%
Sore throat 1.9% 10%-14% 5%-10%
Thrush 0.2%-5% 2% 2%-4%
The above information is edited by the chemicalbook of Tian Ye.
InChI:InChI=1/C32H44O7/c1-18(2)28(36)37-17-25(35)32-26(38-29(39-32)19-8-6-5-7-9-19)15-23-22-11-10-20-14-21(33)12-13-30(20,3)27(22)24(34)16-31(23,32)4/h12-14,18-19,22-24,26-27,29,34H,5-11,15-17H2,1-4H3/t22-,23-,24-,26+,27+,29+,30-,31-,32+/m0/s1

141845-82-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name AC1MIWNR

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

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