141857-34-3

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 5728-52-9 (4-biphenylyl)acetic acid 
• 186581-53-3 diazomethane 
• 141857-33-2 2-Biphenyl-4-yl-3-hydroxy-3-(4-trifluoromethyl-phenyl)-propionic acid 
• 141857-33-2 2-Biphenyl-4-yl-3-hydroxy-3-(4-trifluoromethyl-phenyl)-propionic acid 

Relevant academic research and scientific papers

Nonsteroidal antiinflammatory agents. Part 21: Optically active stereoisomers of p-trifluoromethylphenyl- and p-thioanisyl-biphenylyl-hydroxypropionic acids

The synthesis, diastereomeric separation, assignment to erythro- and threo-configuration by 1HNMR, and optical resolution of 3-(p-trifluoromethyl-phenyl)- and (p-thioanisyl)-2-biphenylyl-3-hydroxypropionic acids are described. The enantiomers were submitted to a preliminary assay to determine antiinflammatory activity.