141872-29-9Relevant articles and documents
DUAL-ACTING ANTIHYPERTENSIVE AGENTS
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Page/Page column 81-82, (2009/04/25)
The invention relates to compounds having the formula: (I) wherein: Ar, r, R3, Z, X, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
SUBSTITUTED CARBAMOYL AND OXYCARBONYL DERIVATIVES OF BIPHENYLMETHYLAMINES
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, (2008/06/13)
Carbamoyl and oxycarbonyl derivatives of biphenylmethylamines of structure I are angiotensin-II antagonists with balanced AT 1 and AT. sub.2 activity useful in the treatment of hypertension and related disorders and ocular hypertension. STR1 where X is--O