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4-[Butyl([2'-(1H-tetrazole-5-yl)[1,1'-biphenyl]-4-yl]methyl)amino]-5-pyrimidinecarboxylic acid is a complex organic compound with a molecular formula of C22H24N6O2. It is characterized by a pyrimidine ring, which is substituted with a carboxylic acid group at the 5-position and an amino group at the 4-position. The amino group is further substituted with a butyl chain and a biphenyl ring, which is itself substituted with a tetrazole group at the 2'-position. 4-[BUTYL([2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL)AMINO]-5-PYRIMIDINECARBOXYLIC ACID is known for its potential applications in medicinal chemistry, particularly as a building block for the development of new drugs or as a chemical intermediate in the synthesis of more complex molecules. Its structure and properties make it a candidate for further research in the field of pharmaceuticals and chemical biology.

141872-46-0

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141872-46-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 141872-46-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,8,7 and 2 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 141872-46:
(8*1)+(7*4)+(6*1)+(5*8)+(4*7)+(3*2)+(2*4)+(1*6)=130
130 % 10 = 0
So 141872-46-0 is a valid CAS Registry Number.

141872-46-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-[butyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]pyrimidine-5-carboxylic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:141872-46-0 SDS

141872-46-0Relevant academic research and scientific papers

2-(Alkylamino)nicotinic Acid and Analogs. Potent Angiotensin II Antagonists

Winn, Martin,De, Biswanath,Zydowsky, Thomas M.,Altenbach, Robert J.,Basha, Fatima Z.,et al.

, p. 2676 - 2688 (2007/10/02)

A series of pyridines and other six-membered ring heterocycles connected to a biphenyltetrazole with a-CH2-NR'-link (1) were discovered to be potent angiotensin II antagonists.In the pyrimidine carboxylic acid series (W = CR, X = N, Y = CH, Z = COOH), compounds with an alkyl group (R') on the exocyclic nitrogen were much more potent than compounds with an alkyl group (R) on the heterocyclic ring.The corresponding pyridine, pyridazine, pyrazine, and 1,2,4-triazine carboxylic acids also showed potent in vitro angiotensin II antagonism.The pyridine (W, X, Y = CH, Z = COOH, R' = n-C3H7) demonstrated potent in vitro activity (pA2 = 10.10, rabbit aorta, and Ki = 0.61 nM, receptor binding in rat liver) as well as exceptional oral antihypertensive activity and bioavailability.Any nonacidic replacement for the carboxylic acid was detrimental for activity.

Angiotensin II receptor antagonists

-

, (2008/06/13)

Compounds are disclosed having the formula: STR1 The compounds of the invention are angiotensin II receptor antagonists.

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