1418733-37-5

Basic information

• Product Name: C₂₉H₃₇N₃O₃
• CAS NO: 1418733-37-5
• Molecular Weight: 475.631
• Mol File: 1418733-37-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₉H₃₇N₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₉H₃₇N₃O₃(1418733-37-5)
• EPA Substance Registry System: C₂₉H₃₇N₃O₃(1418733-37-5)

Safety Data

• Hazardous Substances Data: 1418733-37-5(Hazardous Substances Data)

Upstream product

• 103127-52-2 ((S)-1-benzylallyl)carbamic acid tert-butyl ester 
• 57536-86-4 1-naphtylpiperazine 
• 98760-08-8 (2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane 

Downstream Products

• 1418733-01-3 C₃₈H₅₃N₅O₄ 
• 1418733-00-2 C₄₁H₅₁N₅O₄ 
• 1418732-99-6 C₄₀H₄₉N₅O₄ 
• 1418732-98-5 C₃₈H₄₅N₅O₄ 

Relevant articles and documents

New Cathepsin D inhibitor library utilizing hydroxyethyl isosteres with cyclic tertiary amines

The design and synthesis of hydroxyethylamine isosteres as inhibitors of cathepsin D based on SAR data have been accomplished. A library of 96 of these hydroxyethylamine isosteres are described and many have proven to be very potent inhibitors of human cathepsin D activity as measured using a fluorometric assay technique, via peptide substrate Ac-Glu-Glu(Edans)-Lys-Pro-Ile-Cys-Phe-Phe-Arg- Leu-Gly-Lys(Methyl Red)-Glu-NH2. Compounds showing strongest inhibition of cathepsin D activity were those that contain a hydroxyethyl-N'-2- or N'-(4-chlorophenyl)piperazine moiety (IC50 values range from 0.55 to 8.5 nM), with N'-(2-pyrimidyl)piperizine (IC50 values range from 0.5 to 21.6 nM), with NN'- L-piperazinocolinamide (IC50 values range from 0.001 - 0.25 nM), or N-N'-L-piperazinocolin-N-methylamide (IC50 values range from 0.015 - 7.3 nM) .