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141899-12-9

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141899-12-9 Usage

Chemical Properties

Off-White Solid

Uses

Homo-L-tyrosine hydrobromide is used in the preparation of azoles as oral antidiabetic agents.

Check Digit Verification of cas no

The CAS Registry Mumber 141899-12-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,8,9 and 9 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 141899-12:
(8*1)+(7*4)+(6*1)+(5*8)+(4*9)+(3*9)+(2*1)+(1*2)=149
149 % 10 = 9
So 141899-12-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H13NO3.BrH/c11-9(10(13)14)6-3-7-1-4-8(12)5-2-7;/h1-2,4-5,9,12H,3,6,11H2,(H,13,14);1H/t9-;/m0./s1

141899-12-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-2-Amino-4-(4-hydroxyphenyl)-butanoic acid hydrobromide

1.2 Other means of identification

Product number -
Other names H-HTYR-OH HBR

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:141899-12-9 SDS

141899-12-9Downstream Products

141899-12-9Relevant articles and documents

Preparation and Structure-Activity Relationships of Simplified Analogues of the Antifungal Agent Cilofungin: A Total Synthesis Approach

Zambias, Robert A.,Hammond, Milton L.,Heck, James V.,Bartizal, Ken,Trainor, Charlotte,et al.

, p. 2843 - 2855 (2007/10/02)

The echinocandins are a well-known class of lipopeptides characterized by their potent antifungal activity against Candida species.The mechanism of action of the echinocandins is generally thought to be the inhibition of β-1,3-glucan synthesis, an important structural component in the cell wall of Candida species.Extensive structure-activity studies on the fatty acid side chain of echinocandin B (1) led to the preparation of the clinical candide cilofungin (4).However, little is known about the cyclic peptide.We now report the preparation, by solid-phase synthesis, of a series of simplified analogs of cilofungin in which the unusual amino acids found in the echinocandins were replaced with more readily accesible natural amino acids.The solid-phase approach to the total synthesis of these analogs allowed us to conveniently explore structural modifications that could not be accomlished by chemical modification of the natural product.The simplest analog 5 showed no biological activity.Structural complexity was then returned to the sytem in a systematic fashion so as to reapproach the original cilofungin structure.Antifungal activity and the inhibition of β-1,3-glucan synthesis were monitored at each step of the process, thereby revealing the basic structure-activity relationships of the amino acids and the minimal structural requirements for biological activity in the echinocandin ring system.The results suggests that the 3-hydroxy-4-methylproline residue enhances activity but the L-homotyrosine residue is crucial for both antifungal activity and the inhibition of β-1,3-glucan synthesis.

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