1419075-97-0 Usage
Description
(R,R)-3-Boc-3,6-diaza-bicyclo[3.2.0]heptane is an organic compound with a unique bicyclic structure, featuring two nitrogen atoms and a tert-butoxycarbonyl (Boc) group. It is characterized by its stereochemistry, with both chiral centers being in the R configuration. (R,R)-3-Boc-3,6-diaza-bicyclo[3.2.0]heptane is known for its reactivity and utility in the synthesis of various pharmaceutically relevant molecules.
Uses
Used in Pharmaceutical Industry:
(R,R)-3-Boc-3,6-diaza-bicyclo[3.2.0]heptane is used as a key intermediate in the synthesis of aminotriazines and other related compounds. These compounds have potential applications as inhibitors of ErbB and BTK, which are important targets in the treatment of various cancers and other diseases. The compound's unique structure and reactivity make it a valuable building block for the development of novel therapeutic agents.
Used in Chemical Research:
(R,R)-3-Boc-3,6-diaza-bicyclo[3.2.0]heptane is also utilized as a reagent in chemical research, particularly in the field of organic synthesis. Its ability to form a variety of derivatives and its compatibility with different reaction conditions make it a versatile tool for the preparation of complex organic molecules. Researchers can use this compound to explore new synthetic pathways and develop innovative strategies for the synthesis of bioactive molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 1419075-97-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,1,9,0,7 and 5 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1419075-97:
(9*1)+(8*4)+(7*1)+(6*9)+(5*0)+(4*7)+(3*5)+(2*9)+(1*7)=170
170 % 10 = 0
So 1419075-97-0 is a valid CAS Registry Number.
1419075-97-0Relevant articles and documents
Synthesis and structure-activity relationship studies of 3,6-diazabicyclo[3.2.0]heptanes as novel α4β2 nicotinic acetylcholine receptor selective agonists
Ji, Anguo,Schrimpf, Michael R.,Sippy, Kevin B.,Bunnelle, William H.,Li, Tao,Anderson, David J.,Faltynek, Connie,Surowy, Carol S.,Dyhring, Tino,Ahring, Philip K.,Meyer, Michael D.
, p. 5493 - 5508 (2008/03/13)
A series of novel, potent neuronal nicotinic acetylcholine receptor (nAChR) ligands derived from 3,6-diazabicyclo[3.2.0]heptane have been synthesized and evaluated for binding affinity and agonist activity at the α4β2 nAChR subtype. Structure-activity relationship studies of these novel nAChR ligands focused on substitution effects on the pyridine ring, as well as stereo- and regiochemical influences of the 3,6-diazabicyclo[3.2.0]heptane core. Small 5-substituents on the pyridine ring had a modest impact on the binding affinities and functional activities. 6-Bromo, 6-chloro, and 6-methyl substituents on the pyridine ring led to increased binding affinities and improved functional activities. Most of the 6-N-pyridinyl-substituted 3,6-diazabicyclo[3.2.0]heptanes are selective for the α4β2 nAChR subtype. Compounds (1R,5S)-25, (1R,5S)-55, and (1R,5S)-56 were virtually inactive as agonists at the hα3β4 nAChR but retained potency and efficacy at the hα4β2 nAChR subtype. 3-N-Pyridinyl-substituted series demonstrated more complex SAR. (1R,5R)-39, (1R,5R)-41, and (1R,5R)-42 were found to be much more potent at the hα3β4 nAChR subtype, whereas (1R,5R)-38 and (1R,5R)-40 were very selective at the hα4β2 nAChR subtype. The SAR studies of these novel ligands led to the discovery of several compounds with interesting in vitro pharmacological profiles.
