14191-90-3 Usage
Uses
Different sources of media describe the Uses of 14191-90-3 differently. You can refer to the following data:
1. L-Norarginine is an Arginine (A769500) homolog. Used in the synthesis of derivatives and peptides of α-amino-β-guanidinopropionic acid and α-amino-γ-guanidinobutyric acid.
2. An Arginine (A769500) homolog. Used in the synthesis of derivatives and peptides of α-amino-β-guanidinopropionic acid and α-amino-γ-guanidinobutyric acid.
Check Digit Verification of cas no
The CAS Registry Mumber 14191-90-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,1,9 and 1 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 14191-90:
(7*1)+(6*4)+(5*1)+(4*9)+(3*1)+(2*9)+(1*0)=93
93 % 10 = 3
So 14191-90-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H12N4O2/c6-4(5(10)11)1-2-8-3-9-7/h3-4H,1-2,6-7H2,(H,8,9)(H,10,11)
14191-90-3Relevant articles and documents
Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase
Rossiter, Sharon,Smith, Caroline L.,Malaki, Mohammed,Nandi, Manasi,Gill, Herpreet,Leiper, James M.,Vallance, Patrick,Selwood, David L.
, p. 4670 - 4678 (2005)
The enzyme DDAH metabolizes methylarginines that are inhibitors of nitric oxide synthase (NOS). Substrate-based inhibitors of mammalian DDAH have been synthesized, with optimization to give selective inhibition of DDAH with no significant direct effect on NOSs. These are the first examples of reversible DDAH inhibitors with significant activity and selectivity. In vivo administration increases plasma ADMA levels, giving proof of concept that these inhibitors can be used to probe the physiological effects of DDAH inhibition, with potential for pharmaceutical use of DDAH inhibitors in diseases where excess NO production is implicated.
