1419175-33-9Relevant academic research and scientific papers
KOH-oriented ring openings of N-tosylaziridines with carboxylic acids in DMSO
Zhang,Chang,Wei
, p. 284 - 295 (2015)
A facile and efficient KOH-oriented regioselective ring-opening reaction for the acetolysis of N-tosylaziridines in DMSO was developed under mild conditions. This operationally simple protocol could tolerate a variety of functionalized carboxylic acids as well as several N-tosylaziridines.Moreover, this strategy provided the corresponding ring-opening products with good results.
A carboxylic acid to the aziridine compound open-loop method
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Paragraph 0043; 0082; 0083; 0084; 0085; 0086, (2017/07/31)
The invention discloses a method using carboxylic acid for ring opening of an aziridine compound; a tosyl activated aziridine compound is used as a starting material, in catalyst-free conditions, ring opening of the aziridine compound is performed in N, N-dimethyl formamide solvent by use of carboxylic acid as a nucleophilic reagent. The method is simple in reaction process, uses no catalyst, is mild in conditions, good in environmental protection property, and the method for ring opening has wide universality, and has higher yield and good regioselectivity on the aziridine compounds and carboxylic acid with different structures.
Tetrabutylammonium bromide-mediated ring opening reactions of N-tosylaziridines with carboxylic acids in DMF
Li, Xing,Li, Gong,Chang, Honghong,Zhang, Yan,Wei, Wenlong
, p. 6490 - 6495 (2014/02/14)
Tetrabutylammonium bromide (TBAB) was found to be a highly effective catalyst at as low as 10 mol% for regioselective ring opening of a variety of N-tosylaziridines with various carboxylic acids to afford the corresponding ring-opening products (derived β-amino esters) in good to excellent yields and up to 100% regioselectivity in combination with DMF as the solvent.
