141920-64-1Relevant academic research and scientific papers
Photolactamization: A novel synthetic entry into large ring-sized lactams
Quinkert,Nestler Schumacher,Del Grosso,Durner,Bats
, p. 1977 - 1980 (2007/10/02)
Diene ketenes smoothly accessible by photochemical ring cleavage of o-quinol acetates, in the presence of primary or secondary amines afford the corresponding amides. In an intramolecular version of this reaction macrocyclic lactams of type A are produced, if aminoalkylated o-quinol acetates of type C are used as photoreactants. These photoreactants are available on acid mediated removal of the Boc-protecting group from Wessely acetoxylation products of type D, easily formed via compounds of type E from aminoalkylated phenols of type F.
