1419268-86-2

Basic information

• Product Name: C₁₆H₁₈INOS
• Synonyms: C₁₆H₁₈INOS
• CAS NO: 1419268-86-2
• Molecular Weight: 399.296
• Mol File: 1419268-86-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₈INOS(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₈INOS(1419268-86-2)
• EPA Substance Registry System: C₁₆H₁₈INOS(1419268-86-2)

Safety Data

• Hazardous Substances Data: 1419268-86-2(Hazardous Substances Data)

Upstream product

• 1419268-90-8 C₁₇H₁₆INO₃S 
• 1419268-88-4 C₁₅H₁₁IO₄S 
• 14192-12-2 2,5-diiodobenzoic acid 
• 4892-02-8 Methyl thiosalicylate 

Downstream Products

• 1419268-91-9 C₂₈H₄₅NOSSn 

Relevant articles and documents

A new single-photon emission computed tomography (SPECT) imaging agent for serotonin transporters: [125I]Flip-IDAM, (2-((2-((dimethylamino) methyl)-4-iodophenyl)thio)phenyl)methanol

New ligands for in vivo brain imaging of serotonin transporter (SERT) with single photon emission tomography (SPECT) were prepared and evaluated. An efficient synthesis and radiolabeling of a biphenylthiol, FLIP-IDAM, 4, was accomplished. The affinity of FLIP-IDAM was evaluated by an in vitro inhibitory binding assay using [125I]-IDAM as radioligand in rat brain tissue homogenates (Ki = 0.03 nM). New [125I]Flip-IDAM exhibited excellent binding affinity to SERT binding sites with a high hypothalamus to cerebellum ratio of 4 at 30 min post iv injection. The faster in vivo kinetics for brain uptake and a rapid washout from non-specific regions provide excellent signal to noise ratio. This new agent, when labeled with 123I, may be a useful imaging agent for mapping SERT binding sites in the human brain.