141940-39-8

Basic information

• Product Name: 1-Piperazinecarboxylic acid, 4-(4-fluorophenyl)-, 1,1-dimethylethyl ester
• CAS NO: 141940-39-8
• Molecular Formula: C15H21FN2O2
• Molecular Weight: 280.342
• Mol File: 141940-39-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-Piperazinecarboxylic acid, 4-(4-fluorophenyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazinecarboxylic acid, 4-(4-fluorophenyl)-, 1,1-dimethylethyl ester(141940-39-8)
• EPA Substance Registry System: 1-Piperazinecarboxylic acid, 4-(4-fluorophenyl)-, 1,1-dimethylethyl ester(141940-39-8)

Safety Data

• Hazardous Substances Data: 141940-39-8(Hazardous Substances Data)

Usage

Class

Piperazine

Type

Ester

Use

Synthesis of pharmaceuticals and biologically active compounds

Therapeutic effects

Anti-inflammatory, analgesic

Other properties

Antihypertensive, vasodilatory

Potential medical applications

Treatment of various medical conditions (still under research)

Upstream product

• 460-00-4 1-Bromo-4-fluorobenzene 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 352-34-1 4-fluoro-1-iodobenzene 

Downstream Products

• 2252-63-3 1-(4-Fluorophenyl)piperazine 

Relevant articles and documents

7-benzyl-4-(4-phenylpiperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine derivatives and Composition for skin whitening and Pharmaceutical composition for use in preventing or treating disorders of Melanin Hyperpigmentation containing the same as an active ingredient

The present invention relates to a 7-benzyl-4(4-phenylpiperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine derivative, and to a composition for skin whitening, comprising the same as an active ingredient. Since the derivative exhibits the effect of inhibiting the production of melanin even when used in a small amount, it is useful as a pharmaceutical composition for preventing or treating melanin hyperpigmentation diseases, a cosmetic composition for skin whitening, and a health functional food for skin whitening.

Derisking the Cu-Mediated 18F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands

Molecules labeled with fluorine-18 (18F) are used in positron emission tomography to visualize, characterize and measure biological processes in the body. Despite recent advances in the incorporation of 18F onto arenes, the development of general and efficient approaches to label radioligands necessary for drug discovery programs remains a significant task. This full account describes a derisking approach toward the radiosynthesis of heterocyclic positron emission tomography (PET) radioligands using the copper-mediated 18F-fluorination of aryl boron reagents with 18F-fluoride as a model reaction. This approach is based on a study examining how the presence of heterocycles commonly used in drug development affects the efficiency of 18F-fluorination for a representative aryl boron reagent, and on the labeling of more than 50 (hetero)aryl boronic esters. This set of data allows for the application of this derisking strategy to the successful radiosynthesis of seven structurally complex pharmaceutically relevant heterocycle-containing molecules.

Rhodium(NHC)-catalyzed amination of aryl bromides

(Figure Presented) A rhodium-catalyzed amination reaction of aryl halides with amines has been developed with the use of a N-heterocyclic carbene (NHC) ligand (I/Pr = 1,3-diisopropylimidazol-2-ylidene). The active metal species responsible for the reaction progress was identified. The developed procedure of the Rh-catalyzedW-arylation is convenient to carry out under mild reaction conditions displaying a wide range of substrate scope and high degree of functional group tolerance.