1419611-75-8

Basic information

• Product Name: 6-methoxy-1,3-diphenyl-1H-indazole
• Synonyms: 6-methoxy-1,3-diphenyl-1H-indazole
• CAS NO: 1419611-75-8
• Molecular Weight: 300.36
• Mol File: 1419611-75-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 6-methoxy-1,3-diphenyl-1H-indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methoxy-1,3-diphenyl-1H-indazole(1419611-75-8)
• EPA Substance Registry System: 6-methoxy-1,3-diphenyl-1H-indazole(1419611-75-8)

Safety Data

• Hazardous Substances Data: 1419611-75-8(Hazardous Substances Data)

Upstream product

• 75600-86-1 4-methoxybenzophenone phenylhydrazone 

Relevant articles and documents

Transition-Metal-Free Coupling of 1,3-Dipoles and Boronic Acids as a Sustainable Approach to C?C Bond Formation

The need for alternative, complementary approaches to enable C?C bond formation within organic chemistry is an on-going challenge in the area. Of particular relevance are transformations that proceed in the absence of transition-metal reagents. In the current study, we report a comprehensive investigation of the coupling of nitrile imines and aryl boronic acids as an approach towards sustainable C?C bond formation. In situ generation of the highly reactive 1,3-dipole facilitates a Petasis–Mannich-type coupling via a nucleophilic boronate complex. The introduction of hydrazonyl chlorides as a complementary nitrile imine source to the 2,5-tetrazoles previously reported by our laboratory further broadens the scope of the approach. Additionally, we exemplify for the first time the extension of this protocol into another 1,3-dipole, through the synthesis of aryl ketone oximes from aryl boronic acids and nitrile N-oxides.

[Bis-(trifluoroacetoxy)iodo]benzene-Mediated Oxidative Direct Amination C–N Bond Formation: Synthesis of 1H-Indazoles

An efficient [bis-(trifluoroacetoxy)iodo]benzene (PIFA)-mediated oxidative C-N bond formation is developed for the synthesis of 1H-indazoles from readily available arylhydrazones. The reaction tolerates a wide range of functional groups and has broad scope of substrates. Moreover, this method is a relative green and reliable method for rapid preparation of substituted 1H-indazoles under mild conditions.

Facile access to 1H-indazoles through iodobenzene-catalyzed C-H amination under mild, transition-metal-free conditions

The transition-metal- and halogen-free synthesis of N-aryl-substituted 1H-indazole and derivatives was accomplished on the basis of the iodobenzene-catalyzed intramolecular C-H amination of hydrazones under mild conditions. Reactions of hydrazones derived