141973-58-2

Basic information

• Product Name: Phosphinic amide, N-(2-oxopropyl)-P,P-diphenyl-
• CAS NO: 141973-58-2
• Molecular Formula: C15H16NO2P
• Molecular Weight: 273.271
• Mol File: 141973-58-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Phosphinic amide, N-(2-oxopropyl)-P,P-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphinic amide, N-(2-oxopropyl)-P,P-diphenyl-(141973-58-2)
• EPA Substance Registry System: Phosphinic amide, N-(2-oxopropyl)-P,P-diphenyl-(141973-58-2)

Safety Data

• Hazardous Substances Data: 141973-58-2(Hazardous Substances Data)

Upstream product

• 4020-99-9 diphenylphosphinous acid methyl ester 
• 4504-27-2 1-azidopropan-2-one 

Downstream Products

• 16414-63-4 1-aminopropan-2-one para-toluenesulfonate 

Relevant articles and documents

Reaction of azides with trimethyl phosphite in the presence of water: a chemoselective synthesis of functionalized phosphoramidates

The reductive phosphorylation of azides with trimethyl phosphite and water in THF leads to the corresponding phosphoramidates which are protected primary amines in excellent yields.The P-N bond in these derivatives may be easily cleft in acidic medium to give the primary amine salts.Some examples are reported.The bis-anion 4 obtained by metallation of 3b is C-alkylated at low temperature leading to new phosphoramidates. 3i and 3j derived from α-azidoketones could not be transformed into the corresponding α-aminoketone salts.The use of methyl diphenylphosphinite in place of trimethyl phosphite leads to the diphenylphosphinamide 7 which, when treated with para-toluenesulfonic acid monohydrate in ether, gives the corresponding α-aminoacetone salt 8 in good yield.Keywords: azides / reductive phosphorylation / phosphoramidates / chemoselective reduction / functionalized primary amines