1419752-11-6Relevant articles and documents
Similar but different: Thermodynamic and structural characterization of a pair of enantiomers binding to acetylcholinesterase
Berg, Lotta,Niemiec, Moritz S.,Qian, Weixing,Andersson, C. David,Wittung-Stafshede, Pernilla,Ekstr?m, Fredrik,Linusson, Anna
, p. 12716 - 12720 (2013/02/23)
Take a closer look: Unexpectedly, a pair of enantiomeric ligands proved to have similar binding affinities for acetylcholinesterase. Further studies indicated that the enantiomers exhibit different thermodynamic profiles. Analyses of the noncovalent interactions in the protein-ligand complexes revealed that these differences are partly due to nonclassical hydrogen bonds between the ligands and aromatic side chains of the protein. Copyright