141978-97-4Relevant academic research and scientific papers
Haem d1: Development of a new coupling procedure leading to the synthesis of isobacteriochlorins
Mackman, Richard L.,Micklefield, Jason,Block, Michael H.,Leeper, Finian J.,Battersby, Alan R.
, p. 2111 - 2122 (2007/10/03)
A new approach has been developed for construction of the western and eastern lactams, e.g. 2 and 3, needed for synthesis of isobacteriochlorins. It involves acylation of pyrroles with lactonic acids to form ketones. These are then efficiently converted into the desired lactams by a short sequence of reactions. All the steps are high yielding and simple to carry out.
