141986-94-9

Upstream product

• 141986-92-7 C₁₈H₂₂O₆ 
• 141986-89-2 C₁₄H₁₆O₂ 
• 2886-59-1 1-methoxycyclohexa-1,4-diene 
• 141986-93-8 Acetic acid (1S,2S)-2-acetoxy-4-oxo-cyclohexyl ester 

Downstream Products

• 13314-31-3 (+/-)-(1R,2R,4R)-cyclohexane-1,2,4-triol 

Relevant academic research and scientific papers

Synthesis of (±) cyclohexane-1(R), 2(R), 4(R)-triol-triphosphate, a deoxygenated analog of myo-inositol-1,4,5-triphosphate

For the use in the studies of inositol-phosphates, (±) cyclohexane-1(R), 2(R), 4(R)-triol-triphosphate 2 was synthesized from anisole. The synthesis used 1,2-benzenedimethanol as a ketone and phosphate protective group which induced easy crystallization of the intermediates. Regeneration of the free ketone 9 under mild conditions followed by its selective reduction and phosphorylation by the phosphite method gave the expected compound 2.