1419874-07-9

Upstream product

• 86-93-1 1-Phenyl-1H-tetrazole-5-thiol 
• 1419874-04-6 (S)-3-hydroxy-4-[(1-phenyltetrazole-5-yl)sulfanyl]butyronitrile 
• 1419874-06-8 tert-butyl (5S)-5-hydroxy-3-oxo-6-(1-phenyltetrazole-5-sulfanyl) hexanoate 
• 1419874-05-7 (S)-3-trimethylsiloxy-4-[(1-phenyltetrazole-5-yl)sulfanyl]butyronitrile 

Downstream Products

• 380460-39-9 [(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester 
• 380460-37-7 [(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazole-5-sulfonylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester 

Relevant academic research and scientific papers

INTERMEDIATE OF STATIN DRUGS AND PREPARATION THEREOF

The present invention relates to the field of pharmaceutical chemistry, specifically relates to a statin intermediate having formula I and preparation thereof. The advantages of the method used to prepare the chiral sulfone intermediate having formula I are that a fluorophore is introduced at the beginning of the synthesis, and the intermediates are mostly solid, which enables quality control to be easily carried out.

AN INTERMEDIATE OF STATIN DRUGS AND PREPARATION THEREOF

The present invention relates to the field of pharmaceutical chemistry, specifically relates to a statin intermediate having formula (I) and preparation thereof. The advantages of the method used to prepare the chiral sulfone intermediate having formula (I) are that a fluorophore is introduced at the beginning of the synthesis, and the intermediates are mostly solid, which enables quality control to be easily carried out.