1419967-01-3Relevant academic research and scientific papers
Synthesis and antifungal potential of 3-{4′-(chlorobenzyloxy)-phenyl} -4-amino-5-mercapto-1,2,4-triazolesand their derivatives
Rastogi, Nisheeth,Kant, Padam,Sethi, Rakesh,Harrison, Darwin Anil,Shukla, Sarveshwar
, p. 1235 - 1240 (2013/01/15)
3-{4′-(Chlorobenzyloxy)-phenyl}-4-amino-5-mercapto-1,2,4-triazoies (1a-d) were prepared by treating 4-(chlorobenzyloxy)-benzoylhydrazines successively with alcoholic potassium hydroxide-carbon disulphide and hydrazine hydrate, which on reaction with hydrazine hydrate, carbon disulphide, benzoic acid, benzoin, phenacyl bromide, phenyl isothiocyanate, formic acid, chloroacetyl chloride, benzaldehyde and isatin gave condensed bridgehead heterocycles (triazolo-thiadiazoles and triazolo-thiadiazines). The structures of the compounds were established with the help of elemental analysis and spectral data (IR, PMR and Mass). Compounds were screened for their antimycotic potential against human pathogenic fungi.
