141998-92-7

Usage

Uses

Used in Pharmaceutical Development:
5-Iodo-1-phenyl-1H-pyrazole is used as a key component in the synthesis of pharmaceutical drugs for its potential therapeutic applications in treating various diseases and medical conditions.
Used in Chemical Research and Analysis:
5-Iodo-1-phenyl-1H-pyrazole is utilized as a reagent and reference standard in chemical research and analysis, contributing to the advancement of scientific understanding and the development of new methodologies.
Used in Organic Synthesis:
As a building block, 5-Iodo-1-phenyl-1H-pyrazole is employed in the synthesis of a variety of organic compounds, facilitating the creation of new chemical entities with diverse applications.
Used in Fluorescent Labeling:
Due to its fluorescent nature, 5-Iodo-1-phenyl-1H-pyrazole is used in fluorescent labeling techniques, which are essential in various research areas, including molecular biology and materials science, for visualizing and tracking specific molecules or structures.

Upstream product

• 1126-00-7 1-phenylpyrazole 
• 141998-89-2 1-phenyl-5-tributylstannyl-1H-pyrazole 

Downstream Products

• 1357592-57-4 1-phenyl-5-[(trimethylsilyl)ethynyl]-1H-pyrazole 
• 1357592-64-3 1-phenyl-5-(1-phenyl-1H-pyrazol-5-yl)penta-1,4-diyn-3-one 
• 1357592-62-1 1-phenyl-5-(1-phenyl-1H-pyrazol-5-yl)penta-1,4-diyn-3-ol 
• 1357592-60-9 5-ethynyl-1-phenyl-1H-pyrazole 
• 1357589-34-4 2-(1-phenyl-1H-pyrazol-5-yl)-6-[3-(trifluoromethyl)phenyl]pyridazin-3(2H)-one 

Relevant academic research and scientific papers

N-Heterocyclic Iod(az)olium Salts – Potent Halogen-Bond Donors in Organocatalysis

This article describes the application of N-heterocyclic iod(az)olium salts (NHISs) as highly reactive organocatalysts. A variety of mono- and dicationic NHISs are described and utilized as potent XB-donors in halogen-bond catalysis. They were benchmarked in seven diverse test reactions in which the activation of carbon- and metal-chloride bonds as well as carbonyl and nitro groups was achieved. N-methylated dicationic NHISs rendered the highest reactivity in all investigated catalytic applications with reactivities even higher than all previously described monodentate XB-donors based on iodine(I) and (III) and the strong Lewis acid BF3.

Deprotonative metalation of five-membered aromatic heterocycles using mixed lithium-zinc species

(Equation Presented) Deprotonation of benzoxazole, benzothiazole, benzo[b]thiophene, benzo[b]furan, N-Boc-protected indole and pyrrole, and N-phenylpyrazole using an in situ mixture of ZnCl2·TMEDA (0.5 equiv) and lithium 2,2,6,6-tetramethylpipe

SYNTHESIS AND REACTION OF TRIBUTYLSTANNYLPYRAZOLES

1,3-Dipolar cycloaddition reaction of diazomethane and ethyl diazoacetate with tributylstannylacetylenes occurred regioselectively to afford the corresponding 3(5)-tributylstannylpyrazoles.The cycloaddition reaction of 3-phenylsydnone with the stannylacetylenes proceeded also regioselectively, and 3-tributylstannyl-1-phenylpyrazoles were isolated. 4-Tributylstannyl- and 5-tributylstannyl-1-phenylpyrazole were prepared by the stannylation of 4-lithio- and 5-lithio-1-phenylpyrazoles with tributylstannyl chloride.Iodination, benzoylation, and phenylation of the stannylpyrazoles were examined.