142-79-0

Basic information

• Product Name: PIMELOYL CHLORIDE
• Synonyms: 1,7-HEPTANEDIACID DICHLORIDE;PIMELOYL CHLORIDE;Heptanedioyl dichloride;heptanedioyldichloride;1,7-Heptanediacid dichloride ,98%;Heptanedioic acid dichloride;Pimelic acid dichloride;Pimeloyl dichloride
• CAS NO: 142-79-0
• Molecular Formula: C₇H₁₀Cl₂O₂
• Molecular Weight: 197.06
• EINECS: 205-561-7
• Product Categories: Acid Halides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 142-79-0.mol
• Article Data: 18

Chemical Properties

• Melting Point: 103-105℃
• Boiling Point: 113°C 5mm
• Flash Point: 113 °C
• Appearance: /
• Density: 1.205 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0124mmHg at 25°C
• Refractive Index: n20/D 1.469(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: PIMELOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PIMELOYL CHLORIDE(142-79-0)
• EPA Substance Registry System: PIMELOYL CHLORIDE(142-79-0)

Safety Data

• Hazard Codes: C
• Statements: 34-36/37
• Safety Statements: 26-27-28-36/37/39-45
• RIDADR: 1760
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 142-79-0(Hazardous Substances Data)

Usage

Chemical Properties

Colourless liquid

Uses

Pimeloyl chloride has been used in preparation of:bis-acylureas, by the coupling reaction with ureastriacetyl-15-pimelate-nivalenol, required for production of antibody against nivalenol tetraacetatemacrocyclic tetralactones, via condensation with stannoxane

InChI:InChI=1/C7H10Cl2O2/c8-6(10)4-2-1-3-5-7(9)11/h1-5H2

Upstream product

• 111-16-0 heptanedioic acid 

Downstream Products

• 50905-05-0 N,N'-Dicyclohexylheptandiamid 
• 32246-62-1 1,7-Bis(2,4-dimethoxyphenyl)heptan-1,7-dion 
• 104192-33-8 1,7-Bis-(4-hexyloxy-phenyl)-heptane-1,7-dione 
• 89243-84-5 1,7-Bis(diphenylphosphoryl)-1,7-heptandion 
• 143673-92-1 N,N'-pimeloyldiglycylglycine 
• 54857-47-5 2,2,10,10-tetramethyl-undecane-3,9-dione 
• 84451-93-4 8,8-dimethyl-7-oxo-pelargonic acid 
• 79265-21-7 1,4,12,15-Tetrabenzyl-1,4,12,15-tetraaza-cyclodocosane-5,11,16,22-tetraone 
• 261763-50-2 C₅₇H₆₂Cl₂N₄O₈ 
• 261763-59-1 N-{3-[7-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-7-oxo-heptanoyl]-5-benzyloxy-1-chloromethyl-2,3-dihydro-1H-benzo[e]indol-7-yl}-acetamide 
• 939881-09-1 1,7-bis-[1-(toluene-4-sulfonyl)-1H-pyrrol-3-yl]-heptane-1,7-dione 
• 1189528-20-8 bis(2-(1,3-dioxolan-2-yl)cyclohexyl) heptanedioate 
• 1189528-19-5 bis(2-(1,3-dioxolan-2-yl)cyclohexyl) heptanedioate 
• 26086-87-3 1.7-Bis-p-tolyl-heptan-1.7-dion 

Relevant articles and documents

Bisthioureas of pimelic acid and 4-methylsalicylic acid derivatives as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP): Synthesis and molecular docking studies

Alkaline phosphatases (ALPs) are membrane bound metalloenzymes, distributed all over the body. Recent studies have revealed that by targeting ALPs can lead towards the treatment of many deadliest diseases including cardiac, cancerous and brain diseases. Thioureas and their derivatives are of considerable significance and are privileged scaffolds in medicinal chemistry. They show a wide range of pharmacological activities such as antibacterial, antiparasitic, anti-inflammatory and antioxidants etc. On the other hand, salicylic acid and its derivatives are known for its broad spectrum of activities. The work presented comprises of synthesis of N-acyl-N'-aryl substituted bisthioureas of pimelic acid (1–7) and 3,5-dimethyl pyrazole (11), 1-aroyl-3-aryl thiourea (12) and 1,3,4-oxadiazole (13) derivatives of 4-methyl salicylic acid. Structures of all the synthesized compounds were characterized by FT-IR and 1H NMR spectroscopic analysis. Synthesized compounds were evaluated for their alkaline phosphatases inhibition potential and exhibited high potency as well as selectivity towards h-TNAP and h-IAP. Compound 7 and 12 which were the bisthiourea derivative of pimmelic acid and thiourea derivative of 4-methyl salicylic acid, respectively, showed excellent selectivity against h-TNAP and h-IAP, respectively.

Decarboxylative Borylation of mCPBA-Activated Aliphatic Acids

A decarboxylative borylation of aliphatic acids for the synthesis of a variety of alkylboronates has been developed by mixing m-chloroperoxybenzoic acid (mCPBA)-activated fatty acids with bis(catecholato)diboron in N,N-dimethylformamide (DMF) at room temperature. A radical chain process is involved in the reaction which initiates from the B-B bond homolysis followed by the radical transfer from the boron atom to the carbon atom with subsequent decarboxylation and borylation.

Thermotropic liquid crystalline polyesters derived from 2-chloro hydroquinone

Abstract: Synthesis of thermotropic liquid crystalline polyesters derived from bis[4-hydroxy benzoyloxy]-2-chloro-1,4-benzene (BHBOCB) and aliphatic dicarboxylic acid chlorides by interfacial polycondensation methodology is presented. Synthesised polyesters consist of bis[4-hydroxy benzoyloxy]-2-chloro-1,4-benzene as a mesogen and aliphatic diacid chloride as flexible spacer. The length of oligomethylene units in the polymer was varied from the trimethylene to the dodecamethylene groups. Synthesized polyesters were characterized by differential scanning calorimetry and optical microscopy. The transition temperatures and thermodynamic properties were studied for all these polymers. These polyesters exhibited thermotropic liquid crystalline behavior and showed nematic texture except decamethylene spacer. Decamethylene spacer based polyester showed marble texture of smectic C. Mesophase stability of these polyesters was higher than 123 °C (except first heating cycle of PE-1). Graphical Abstract:: SYNOPSIS The present study deals with the synthesis of thermotropic liquid crystalline polyesters derived from bis[4-hydroxy benzoyloxy]-2-chloro-1,4-benzene (BHBOCB) and aliphatic dicarboxylic acid chlorides by interfacial polycondensation methodology. [Figure not available: see fulltext.].