1420161-03-0Relevant academic research and scientific papers
Copper-catalyzed tandem asymmetric borylation of β-chloroalkyl aryl ketones and related compounds
Jiang, Quanbin,Guo, Tenglong,Yu, Zhengkun
, p. 660 - 665 (2015)
The Cu-catalyzed, one-pot tandem (asymmetric) borylation of β-chloroalkyl aryl ketones via the in situ generated acyclic enones with bis(pinacolato)diboron was achieved efficiently to reach up to 97% yield and 99% enantioselectivity for the formal sp3 C-Cl borylation products. The present methodology provides an efficient alternative route to (chiral) alkylboron compounds. In situ generation works better! Copper-catalyzed (asymmetric) borylation of β-chloroalkyl aryl ketones via in situ generated enones has been realized with bis(pinacolato)diboron (B2pin2) to achieve up to 97% yield and 99% enantioselectivity. β-Chloroalkyl aryl ketones are a class of effective precursors to acyclic enones, and the present methodology provides an efficient alternative route to (chiral) organoboron compounds.
Synthesis of fluorine-substituted [2.2]paracyclophane-based carbene precursors for copper-catalyzed enantioselective boration of α,β-unsaturated ketones
Wang, Linyong,Ye, Meng,Wang, Lei,Duan, Wenzeng,Song, Chun,Ma, Yudao
, p. 54 - 61 (2017/01/10)
Fluorine-substituted [2.2]paracyclophane-based carbene precursors have been successfully synthesized and applied to copper-catalyzed asymmetric β-boration of α,β-unsaturated ketones. Fluorination of the planar chiral carbenes has a beneficial impact on th
Enantioselective β-boration of acyclic enones by a [2.2]paracyclophane-based N-heterocyclic carbene copper(I) catalyst
Zhao, Lei,Ma, Yudao,He, Fuyan,Duan, Wenzeng,Chen, Jianqiang,Song, Chun
, p. 1677 - 1681 (2013/03/28)
A new planar and centrally chiral bicyclic 1,2,4-triazolium salt has been synthesized from [2.2]paracyclophane and phenylglycinol. The N-heterocyclic carbene (NHC) copper(I) complex generated in situ by the reaction of the triazolium salt and Cu2/su
