1420295-80-2Relevant academic research and scientific papers
Discovery of 3-arylquinoxaline derivatives as potential anti-dengue virus agents
Tseng, Chih-Hua,Han, Cheng-Ruei,Tang, Kai-Wei
, (2019/10/28)
We designed and synthesized a series of novel 3-arylquinoxaline derivatives and evaluated their biological activities as potential dengue virus (DENV) replication inhibitors. Among them, [3-(4-methoxyphenyl)quinoxalin-2-yl](phenyl)methanol (19a), [6,7-dic
Multifold bond cleavage and formation between meoh and quinoxalines (or benzothiazoles): Synthesis of carbaldehyde dimethyl acetals
Liu, Yunkui,Jiang, Bo,Zhang, Wei,Xu, Zhenyuan
, p. 966 - 980 (2013/04/10)
A K2S2O8-mediated direct cross-coupling of quinoxalines (or benzothiazoles) with methanol leading to 2-quinoxalinyl (or 2-benzothiazolyl) carbaldehyde dimethyl acetals has been achieved. 2-Quinoxalinyl carbaldehyde dimethyl acetals were readily converted into 2-quinoxalinyl carbaldehydes in good to excellent yields under acidic conditions. Preliminary mechanistic studies suggest that the reaction proceeds via multifold bond cleavage and formation between methanol and N-heterocycles involving a dioxygen-participated radical process. This method allows for the synthesis of a variety of 2-quinoxalinyl (or 2-benzothiazolyl) carbaldehyde dimethyl acetals directly via cross-coupling of simple N-heterocyclic C-H bond and methanol under aldehyde-, acid-, and transition-metal-free conditions.
