1420372-82-2

Basic information

• Product Name: O-(benzothiazol-2-yl)-N-methylhydroxylamine
• Synonyms: O-(benzothiazol-2-yl)-N-methylhydroxylamine
• CAS NO: 1420372-82-2
• Molecular Weight: 180.23
• Mol File: 1420372-82-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: O-(benzothiazol-2-yl)-N-methylhydroxylamine(CAS DataBase Reference)
• NIST Chemistry Reference: O-(benzothiazol-2-yl)-N-methylhydroxylamine(1420372-82-2)
• EPA Substance Registry System: O-(benzothiazol-2-yl)-N-methylhydroxylamine(1420372-82-2)

Safety Data

• Hazardous Substances Data: 1420372-82-2(Hazardous Substances Data)

Upstream product

• 149-30-4 2-Mercaptobenzothiazole 
• 593-77-1 N-Methylhydroxylamine 
• 433-17-0 benzothiazole-2-sulfonamide 

Relevant articles and documents

Hydroxylamine as an oxygen nucleophile: Substitution of sulfonamide by a hydroxyl group in benzothiazole-2-sulfonamides

Benzothiazole-2-sulfonamides react with an excess of hydroxylamine in aqueous solutions to form 2-hydroxybenzothiazole, sulfur dioxide, and the corresponding amine. Mechanistic studies that employ a combination of structure-reactivity relationships, oxygen labeling experiments, and (in)direct detection of intermediates and products reveal that the reaction proceeds via oxygen attack, and that oxygen incorporated in the 2-hydroxybenzothiazole product derives from hydroxylamine. The reaction, which is performed under mild conditions, can be used as a deprotection method for cleavage of benzothiazole-2-sulfonyl-protected amino acids.