142044-85-7

Basic information

• Product Name: 1-(2-BROMO-4-METHYL-PHENYL)-1H-PYRROLE
• Synonyms: 1-(2-BROMO-4-METHYL-PHENYL)-1H-PYRROLE
• CAS NO: 142044-85-7
• Molecular Formula: C₁₁H₁₀BrN
• Molecular Weight: 236.11
• Mol File: 142044-85-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 307.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.34±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -5.90±0.70(Predicted)
• CAS DataBase Reference: 1-(2-BROMO-4-METHYL-PHENYL)-1H-PYRROLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-BROMO-4-METHYL-PHENYL)-1H-PYRROLE(142044-85-7)
• EPA Substance Registry System: 1-(2-BROMO-4-METHYL-PHENYL)-1H-PYRROLE(142044-85-7)

Safety Data

• Hazardous Substances Data: 142044-85-7(Hazardous Substances Data)

Usage

General Description

1-(2-Bromo-4-methyl-phenyl)-1H-pyrrole is a chemical compound with the molecular formula C11H10BrN. It is a derivative of pyrrole, a five-membered aromatic ring containing one nitrogen atom. The compound contains a bromine atom and a methyl group attached to the phenyl ring. It is commonly used in pharmaceutical research and organic synthesis. The compound has potential applications as a building block in the production of various pharmaceuticals and agrochemicals, as well as in materials science and other industrial processes. Its unique structure and properties make it a valuable tool for chemical research and development.

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 583-68-6 2-bromo-p-toluidine 

Downstream Products

• 142045-46-3 1-(2-bromo-4-methyl-phenyl)-1H-pyrrole-2-carbaldehyde 
• 142045-04-3 1-(2-bromo-4-methylphenyl)pyrrole-2-carbonitrile 

Relevant articles and documents

A solvent-free manganese(II) -catalyzed Clauson-Kaas protocol for the synthesis of N-aryl pyrroles under microwave irradiation

The first manganese-catalyzed modified Clauson-Kaas reaction for N-substituted pyrrole synthesis using 2,5-dimethoxytetrahydrofuran with variously substituted aromatic amines has been developed (up to 89% yield). This interesting neat strategy is free from additives including co-catalysts, ligands, and acids. Relatively low cost, environmentally benign, and handy Mn(NO3)2·4H2O is employed as the catalyst under microwave conditions with a very short reaction time (20?min). The above qualities attest to the green nature of this reaction.

One-Pot Synthesis of Pyrrolo[1,2- a ]quinoxaline Derivatives via a Copper-Catalyzed Aerobic Oxidative Domino Reaction

A copper-catalyzed process for the synthesis of pyrrolo[1,2-a]quinoxalines from readily available α-amino acids and 1-(2-halophenyl)-1H-pyrroles is described. Different functional groups were well tolerated to give the corresponding products.

ANGIOTENSIN II ANTAGONIZING HETEROCYCLIC DERIVATIVES

The invention relates to compounds of the formula STR1 wherein STR2 represents a condensed or uncondensed imidazolyl ring and the rest of the variables are as defined in the specification. They are angiotensin II antagonists useful for treating hypertension, etc..