1420467-59-9

Basic information

• Product Name: C₁₈H₁₀N₂O₇S
• Synonyms: C₁₈H₁₀N₂O₇S
• CAS NO: 1420467-59-9
• Molecular Weight: 398.353
• Mol File: 1420467-59-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₀N₂O₇S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₀N₂O₇S(1420467-59-9)
• EPA Substance Registry System: C₁₈H₁₀N₂O₇S(1420467-59-9)

Safety Data

• Hazardous Substances Data: 1420467-59-9(Hazardous Substances Data)

Upstream product

• 23204-38-8 3-amino-naphthalene-1,8-dicarboxylic acid-anhydride 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 

Relevant articles and documents

Ligand-based discovery of N-(1,3-dioxo-1H,3H-benzo[de]isochromen-5-yl)- carboxamide and sulfonamide derivatives as thymidylate synthase A inhibitors

Phenolnaphthalein derivatives show potential for pharmacological activity as inhibitors of thymidylate synthase (TS) but difficulties in their synthesis and derivatization hinder their development. A deconstruction approach aimed at identifying a suitable new scaffold was proposed. A new scaffold was identified and two compound libraries based on this scaffold were designed. The carboxamide library (Library B) showed specific inhibition activity against Escherichia coli TS, whereas the sulfonamide library (Library C) showed a non-specific inhibition profile against hTS. N-(1,3-Dioxo-1H,3H-benzo[de]isochromen-5-yl)- sulfonamide derivatives, 1C and 9C, showed one order of magnitude improvement in inhibition constant against hTS with respect to the starting lead and represent potential compounds for further lead development.