1420588-23-3Relevant academic research and scientific papers
Novel hybrids of natural isochroman-4-one bearing N-substituted isopropanolamine as potential antihypertensive candidates
Bai, Renren,Huang, Xiaojing,Yang, Xue,Hong, Wen,Tang, Yiqun,Yao, Hequan,Jiang, Jieyun,Liu, Jie,Shen, Mingqin,Wu, Xiaoming,Xu, Jinyi
, p. 2495 - 2502 (2013)
A series of novel hybrids of natural isochroman-4-one bearing isopropanolamine moiety were designed, synthesized and evaluated for their antihypertensive activity. It was found that compound IIId, prepared by hybridizing N-isopropyl substituted isopropanolamine functionality to a phenolic oxygen of isochroman-4-one, exhibited potent β1-adrenoceptor blocking effect comparable to the well-known antihypertensive drug propranolol. Additionally, IIId significantly reduced the systolic and diastolic blood pressure in SHRs by over 40%, which was obviously stronger than the lead compounds 7,8-dihydroxy-3-methyl-isochroman-4-one (XJP) and its analogue XJP-B. Overall, IIId may be a promising antihypertensive candidate for further investigation.
