14207-97-7

Upstream product

• 63368-34-3 (3,4-dimethoxybenzyl)triphenylphosphonium chloride 
• 121-33-5 vanillin 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 93-03-8 (3,4-dimethoxyphenyl)methanol 
• 7306-46-9 4-chloromethyl-1,2-dimethoxy-benzene 
• 6379-72-2 1,2-dimethoxy-4-(E)-propenylbenzene 
• 5932-68-3 (E)-2-methoxy-4-(1-propenyl)phenol 
• 54208-27-4 Acetic acid 4-[(E)-2-(3,4-dimethoxy-phenyl)-vinyl]-2-methoxy-phenyl ester 

Relevant academic research and scientific papers

Design, synthesis and antitumour and anti-angiogenesis evaluation of 22 moscatilin derivatives

Two series of moscatilin derivatives were designed, synthesized and evaluated as anti-tumor and anti-angiogenesis agents. Most of these compounds showed moderate-to-obvious cytotoxicity against five cancer cell lines (A549, HepG2, MDA-MB-231, MKN-45, HCT116). Among these cell lines, compounds had obvious effects on HCT116. Especially for 8Ae, the IC50 was low to 0.25 μM. 8Ae can inhibit the viability and induce the apoptosis of HCT116 cells but exhibit no cytotoxic activity in noncancerous NCM460 colon cells. 8Ae can also arrest the G2/M cell cycle in HCT116 cells by inhibiting the α-tubulin expression. Zebrafish bioassay-guided screen showed the 22 moscatilin derivatives had potent anti-angiogenic activities and compound 8Ae had better activities than positive compound. Molecular docking indicated 8Ae interacted with tubulin at the affinity of ?7.2 Kcal/mol. In conclusion, compound 8Ae was a potential antitumor and anti-angiogenesis candidate for further development.

POLYHYDROXYLATED (1-PHENYL-2-PHENYL) ETHYLENE DERIVATIVES AS AN ANTI-AGEING AND PHOTOPROTECTIVE AGENT

The present invention is directed towards the cosmetic use of at least one compound of formula (I) and/or solvates thereof and/or stereoisomers thereof: formula (I) in which groups A and B are different and: - A—* represents a disubstituted phenyl radical: formula (I′) - B—** represents a mono- or disubstituted phenyl radical: formula (I′′) or of a composition comprising, in a physiologically acceptable medium, at least one compound of formula (I), for treating and/or preventing the signs of ageing and/or of photoageing of keratin materials, preferably of the skin.

Nucleophilicity and Basicity of Phenols in the Aminolysis of Corresponding Aryl Acetates with Piperidine

A correlation was found between the nucleophilicity and basicity of phenols in the aminolysis of corresponding aryl acetates with piperidine. The correlation is satisfactorily described by the Bronsted equation. The nucleophilicity of low-molecular-weight phenols and phenol oligomers of vegetable origin (lignins) was estimated.