142074-98-4Relevant academic research and scientific papers
Highly regio- and enantioselective heck reaction of N-methoxycarbonyl-2- pyrroline with planar chiral diphosphine-oxazoline ferrocenyl ligands
Tu, Tao,Hou, Xue-Long,Dai, Li-Xin
, p. 3651 - 3653 (2003)
(Matrix presented) A series of planar chiral diphosphine-oxazoline ferrocene ligands were effectively applied in the asymmetric arylation of N-methoxycarbonyl-2-pyrroline, and up to 99% ee was observed for the product 3. The regioselectivity of this reaction was strongly affected by the different precursors of the palladium species and the polarity of the solvent.
Highly regio- and enantioselective heck reactions of N-substituted 2-pyrroline with the new chiral ligand BITIANP
Tietze,Thede
, p. 1470 - 1472 (2007/10/03)
The intermolecular Heck reaction of N-substituted 2-pyrroline 4 with aryl triflates 5a-d in the presence of the chiral ligand (S)-BITIANP 1 gives the N-substituted 5-aryl-2-pyrrolines 6a-d highly regioselectively with excellent enantioselectivity (93-95%
Catalytic asymmetric arylation of N-substituted 2-pyrrolines with aryl triflates
Ozawa, Fumiyuki,Hayashi, Tamio
, p. 267 - 277 (2007/10/02)
Catalytic asymmetric arylation of 1-(alkoxycarbonyl)-2-pyrrolines (4) with aryl triflates (1) in benzene in the presence of a base and a palladium catalyst, prepared in situ by mixing Pd(OAc)2 and (R)-BINAP, gives optically active (R)-1-(alkoxycarbonyl)5-aryl-2-pyrrolines (5) of up to 83percent ee. together with the regioisomers 1-(alkoxycarbonyl)-5-aryl-3-pyrrolines (6).
