1420766-50-2

Upstream product

• 156633-81-7 (2R,3S)-3,7-dimethyl-6-octene-1,2-diol 
• 1420766-47-7 (3S,4S,9S)-4-(tert-butyldimethylsilyloxy)-10-(tert-butyldiphenylsilyloxy)-3,9-dimethyl-decan-1-ol 
• 1420766-44-4 (5S,10S)-5-((S)-but-3-en-2-yl)-2,2,3,3,10,14,14-heptamethyl-13,13-diphenyl-4,12-dioxa-3,13-disilapentadecane 
• 1420766-36-4 (2R,3S,8S)-1-((S)-4-benzyl-2-thioxothiazolidin-3-yl)-3-(tert-butyldimethylsilyloxy)-9-(tert-butyldiphenylsilyloxy)-2,8-dimethylnonan-1-one 
• 1420766-39-7 (2S,3S,8S)-3-(tert-butyldimethylsilyloxy)-9-(tert-butyldiphenylsilyloxy)-2,8-dimethylnonan-1-ol 
• 1420766-33-1 (2R,3S,8S)-1-((S)-4-benzyl-2-thioxothiazolidin-3-yl)-9-(tert-butyldiphenylsilyloxy)-3-hydroxy-2,8-dimethylnonan-1-one 
• 1420766-25-1 ethyl (S)-7-((tert-butyldiphenylsilyl)oxy)-6-methylheptanoate 
• 1420766-22-8 (S,E)-ethyl 7-(tert-butyldiphenylsilyloxy)-6-methylhept-2-enoate 
• 1420766-19-3 (S)-tert-butyl(2,6-dimethylhept-5-enyloxy)diphenylsilane 
• 161512-73-8 (2S)-2,6-dimethyl-5-hepten-1-ol 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 1420766-88-6 C₃₃H₅₄O₃Si₂ 
• 1420766-28-4 C₂₄H₃₄O₂Si 

Downstream Products

• 1420766-91-1 methyl 2-((2S,4S,5S)-5-(6-(tert-butyldiphenylsilyloxy)hexyl)-4-methyltetrahydrofuran-2-yl)acetate 
• 1269803-20-4 (S)-((4R,8R)-9-(benzyloxy)-8-methyl-6-methylenenonan-4-yl)-6-((2S,3S,5R)-5-(2-(4-methoxybenzyloxy)ethyl)-3-methyltetrahydrofuran-2-yl)-2-methylhexanoate 
• 1420766-53-5 (5S,6S,11S,E)-methyl 12-(tert-butyldiphenylsilyloxy)-6-hydroxy-5,11-dimethyldodec-2-enoate 
• 1420766-56-8 methyl 2-((2R,4S,5S)-5-(6-(tert-butyldiphenylsilyloxy)hexyl)-4-methyltetrahydrofuran-2-yl)acetate 
• 1420766-59-1 2-((2R,4S,5S)-5-((S)-6-(tert-butyldiphenylsilyloxy)-5-methylhexyl)-4-methyltetra-hydrofuran-2-yl)ethanol 
• 1420766-62-6 tert-butyl((S)-6-((2S,3S,5R)-5-(2-(4-methoxybenzyloxy)ethyl)-3-methyltetrahydrofuran-2-yl)-2-methylhexyloxy)diphenylsilane 
• 1269803-28-2 (S)-6-{(2S,3S,5R)-5-[2-(4-methoxybenzyloxy)ethyl]-3-methyltetrahydrofuran-2-yl}-2-methylhexan-1-ol 
• 1269803-11-3 (S)-6-{(2S,3S,5R)-5-[2-(4-methoxybenzyloxy)ethyl]-3-methyltetrahydrofuran-2-yl}-2-methylhexanoic acid 

Relevant academic research and scientific papers

Formal synthesis of amphidinin B

An efficient, convergent, and highly stereoselective formal synthesis of amphidinin B (1) is reported herein. In Amphidinin B both C10-C21 (4) and C1-C9 (5) fragments were derived from geraniol 6 and mono-PMB ether of 1,4-butane diol 7 in 19 and 9 steps, respectively. The key steps involved in this synthesis are Sharpless asymmetric epoxidation, Evans aldol, Julia olefination, oxa-Michael, Keck allylation, Mannich reaction, Evans asymmetric alkylation, and Yamaguchi esterification.