142087-70-5Relevant academic research and scientific papers
The Synthesis of Optically Active P-Phenyl-P-(2,4,6-trimethylphenyl)phosphinamide and an X-Ray Structure of (-)-(1R)-N-(1-Phenylethyl)-(SP)-P-phenyl-P-(2,4,6-trimethylphenyl)phosphinamide
Hamor, Thomas A.,Jennings, W. Brian,Lovely, Carl J.,Reeves, Keith A.
, p. 843 - 849 (2007/10/02)
The primary phosphinic amide P-phenyl-P-(2,4,6-trimethylphenyl)phosphinamide has been prepared in optically active form (75percent enantiomeric excess) in six steps from dichlorophenylphosphine.The configuration of the intermediate N-(1-phenylethyl)-P-phenyl-P-(2,4,6-trimethylphenyl)phosphinamide has been established by an X-ray crystal structure determination of the minor diastereoisomer.This compound exhibits in the solid state two independent rotameric conformations about the P-N bond.Geometry optimisation by MNDO MO calculations refined these to the same rotamer having the nitrogen lone pair anticlinal to the P-O bond.
