1421045-75-1

Upstream product

• 536-74-3 phenylacetylene 
• 503321-04-8 (2S,5R,6R)-5,6-dimethoxy-5,6-dimethyl-[1,4]dioxane-2-carbaldehyde 
• 1421045-66-0 2,2,2-trichloro-N-((S,E)-4-((2R,5R,6R)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-yl)-2-phenylbut-3-en-2-yl)acetamide 
• 1421045-58-0 (R,E)-1-((2S,5R,6R)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-yl)-3-phenylbut-2-en-1-ol 

Downstream Products

• 365442-14-4 (R)-2-((tert-butoxycarbonyl)amino)-2-phenylpropanoic acid 
• 1421045-74-0 tert-butyl ((S,E)-4-((2R,5R,6R)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-yl)-2-phenylbut-3-en-2-yl)carbamate 

Relevant academic research and scientific papers

Preparation of chiral α-substituted alaninates through an efficient diastereoselective synthesis of trisubstituted allylic alcohols

Tri without fail: The highly diastereoselective addition of vinylaluminum reagents, generated in situ from the zirconium-catalyzed carboalumination of various alkynes and Me3Al, to the easily accessible (2S,5R,6R)-5,6-dimethyl-[1,4]dioxane-2-carbaldehyde (1 b) afforded the corresponding trisubstituted allylic alcohols, and a subsequent Overman reaction yielded allylic amines that contain chiral quaternary carbon stereocenters. Copyright