1421227-53-3 Usage
Description
N-(6-(4-(2-((4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)amino)-2-oxoethyl)phenoxy)pyrimidin-4-yl)cyclopropanecarboxamide is a complex organic compound with a unique molecular structure. It is characterized by its multiple functional groups, including a cyclopropanecarboxamide moiety, a pyrimidinyl group, and a trifluoromethylphenyl group. N-(6-(4-(2-((4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)amino)-2-oxoethyl)phenoxy)pyrimidin-4-yl)cyclopropanecarboxamide has potential applications in various fields due to its structural diversity and functional groups.
Uses
1. Used in Pharmaceutical Industry:
N-(6-(4-(2-((4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)amino)-2-oxoethyl)phenoxy)pyrimidin-4-yl)cyclopropanecarboxamide is used as a potential therapeutic agent for the treatment and cure of diabetes type I. It acts as a β-cell proliferation inducer via the IκB kinase pathway and modulation of the Erb3 binding-protein, which can help in the regeneration and maintenance of insulin-producing cells in the pancreas.
2. Used in Chemical Research:
N-(6-(4-(2-((4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)amino)-2-oxoethyl)phenoxy)pyrimidin-4-yl)cyclopropanecarboxamide can also be utilized in chemical research for the development of new drugs and materials. Its unique structure and functional groups make it a valuable starting point for the synthesis of novel compounds with potential applications in various industries, such as pharmaceuticals, agrochemicals, and materials science.
3. Used in Material Science:
Due to its structural diversity and the presence of various functional groups, N-(6-(4-(2-((4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)amino)-2-oxoethyl)phenoxy)pyrimidin-4-yl)cyclopropanecarboxamide can be explored for its potential applications in material science. It may be used in the development of new polymers, coatings, or other materials with specific properties, such as improved stability, enhanced mechanical strength, or unique optical characteristics.
Biological Activity
ws6 is a small-molecule inducer of β cell proliferation [1].β cells are a subset of cells in the pancreatic islets and play an important role in regulating glucose homeostasis through the production of insulin [1].ws6 is a small-molecule inducer of β cell proliferation. in mouse β cell line r7t1, ws6 induced cell proliferation with ec50 value of 0.28 μm. ws6 was very active in primary human and rodent islets. in primary rat and human β cells, ws6 induced rat β cell proliferation with ec50 value of 0.4 μm and increased 4% of rat β cells and 3% of human β cells to proliferate. in intact islet cultures, ws6 significantly induced proliferation [1]. in cultured human islets, ws6 induced β cell proliferation and also α cell proliferation. however, ws6 didn’t influence the expression of β cell-specific transcription factors and the amount of insulin-positive β cells, which suggested that ws6 didn’t influence β cell differentiation and human islet cell viability [2].in type 1 diabetes (t1d) mice, ws6 significantly reduced blood glucose and increased β cell proliferation from 3.8% to 6.4% [1].
references
[1]. shen w, tremblay ms, deshmukh va, et al. small-molecule inducer of β cell proliferation identified by high-throughput screening. j am chem soc, 2013, 135(5): 1669-1672. [2]. boerner bp, george nm, mir su, et al. ws6 induces both alpha and beta cell proliferation without affecting differentiation or viability. endocr j, 2015, 62(4): 379-386.
Check Digit Verification of cas no
The CAS Registry Mumber 1421227-53-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,1,2,2 and 7 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1421227-53:
(9*1)+(8*4)+(7*2)+(6*1)+(5*2)+(4*2)+(3*7)+(2*5)+(1*3)=113
113 % 10 = 3
So 1421227-53-3 is a valid CAS Registry Number.
1421227-53-3Relevant articles and documents
Small-molecule inducer of β cell proliferation identified by high-throughput screening
Shen, Weijun,Tremblay, Matthew S.,Deshmukh, Vishal A.,Wang, Weidong,Filippi, Christophe M.,Harb, George,Zhang, You-Qing,Kamireddy, Anwesh,Baaten, Janine E,Jin, Qihui,Wu, Tom,Swoboda, Jonathan G.,Cho, Charles Y.,Li, Jing,Laffitte, Bryan A.,McNamara, Peter,Glynne, Richard,Wu, Xu,Herman, Ann E.,Schultz, Peter G.
, p. 1669 - 1672 (2013/04/23)
The identification of factors that promote β cell proliferation could ultimately move type 1 diabetes treatment away from insulin injection therapy and toward a cure. We have performed high-throughput, cell-based screens using rodent β cell lines to ident
