1421230-76-3

Upstream product

• 16234-10-9 3H-thieno[3,2-d]pyrimidin-4-one 
• 1421230-75-2 methyl 3-(4-(4-chlorothieno[3,2-d]pyrimidin-7-yl)phenyl)propanoate 
• 1421230-74-1 methyl 3-(4-(4-(methylthio)thieno[3,2-d]pyrimidin-7-yl)phenyl)propanoate 
• 1246223-38-0 7-bromo-4-(methylsulfanyl)thieno[3,2-d]pyrimidine 
• 31169-27-4 7-bromo-4-chlorothieno[3,2-d]pyrimidine 
• 31169-25-2 7-bromothieno[3,2-d]pyrimidine-4(3H)-one 

Downstream Products

• 1421230-68-3 3-(4-(4-(3-(3-chlorophenyl)ureido)thieno[3,2-d]pyrimidin-7-yl)phenyl)propanoic acid 

Relevant academic research and scientific papers

NOVEL PYRIMIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION INCLUDING SAME AS AN ACTIVE INGREDIENT

The present invention relates to a compound represented by formula (I) for inhibiting the activity of diacylglycerol O-acyltransferase type 1 (DGAT1), and pharmaceutically acceptable salts thereof, and a pharmaceutical composition comprising same as an active ingredient. The compound of the present invention may be used effectively in the treatment or prevention of a disease or condition mediated by the activity of DGAT1 such as obesity, type II diabetes, dyslipidemia, metabolic syndrome, and the like, without any adverse effects: wherein A, B, X, and R5 to R7 are the same as defined in the specification.

NOVEL PYRIMIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION INCLUDING SAME AS AN ACTIVE INGREDIENT

The present invention relates to a compound represented by formula (I) for inhibiting the activity of diacylglycerol O-acyltransferase type 1 (DGAT1), and pharmaceutically acceptable salts thereof, and a pharmaceutical composition comprising same as an active ingredient. The compound of the present invention may be used effectively in the treatment or prevention of a disease or condition mediated by the activity of DGAT1 such as obesity, type II diabetes, dyslipidemia, metabolic syndrome, and the like, without any adverse effects: wherein A, B, X, and R5 to R7 are the same as defined in the specification.