1421256-78-1Relevant articles and documents
Solvent-controlled, regio-switchable formation of 3-/5-arylaminopyrazole isomer in cyclocondensation of β-aminoenones with hydrazides: Intermolecular hydrogen bonding plays a role
Xiang, Dexuan,Bi, Xihe,Liao, Peiqiu,Fang, Guichun,Wang, Zikun,Xin, Xiaoqing,Dong, Dewen
, p. 386 - 389 (2013/03/28)
An unprecedented solvent-controlled, regio-switchable Knorr-type reaction for the synthesis of pyrazoles has been realized in the cyclocondensation of β-aminoenones with hydrazides. Single regioisomer of 3- or 5-arylaminopyrazole can be obtained simply by changing the reaction solvent. Using hydrazine hydrate, only 3-arylaminopyrazoles were produced.