1421275-66-2 Usage
Uses
Used in Organic Synthesis:
2,5-dimethyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-pyrrole is used as a key intermediate in organic synthesis for the creation of new compounds and materials. Its unique structure allows for further functionalization and modification, making it a versatile building block in the synthesis of complex organic molecules.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 2,5-dimethyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-pyrrole is used as a precursor in the development of new drugs. Its boron-containing group can be utilized in cross-coupling reactions to form carbon-carbon bonds, which are essential in the synthesis of various pharmaceutical compounds.
Used in Material Science:
2,5-dimethyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-pyrrole is used as a component in the development of advanced materials. Its pyrrole ring and boron-containing group can contribute to the formation of novel materials with unique properties, such as conductivity, stability, or specific interactions with other molecules.
Used in Cross-Coupling Reactions:
In the field of organic chemistry, 2,5-dimethyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-pyrrole is used as a reactant in cross-coupling reactions. Its boron-containing group facilitates the formation of carbon-carbon bonds, which are crucial for the synthesis of complex organic molecules and the construction of molecular frameworks in various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1421275-66-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,1,2,7 and 5 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1421275-66:
(9*1)+(8*4)+(7*2)+(6*1)+(5*2)+(4*7)+(3*5)+(2*6)+(1*6)=132
132 % 10 = 2
So 1421275-66-2 is a valid CAS Registry Number.
1421275-66-2Relevant academic research and scientific papers
Synthesis and biological activity of new 4-(Pyridin-4-yl)-(3-methoxy-5- methylphenyl)- 1H-pyrazoles derivatives as ROS Receptor tyrosine kinase inhibitors
Park, Byung Sun,El-deeb, Ibrahim M.,Yoo, Kyung Ho,Han, Dong Keun,Tae, Jin Sung,Lee, So Ha
, p. 3629 - 3634 (2013/01/16)
A series of new 4-(pyridin-4-yl)-(3-methoxy-5-methylphenyl)-1H-pyrazoles (6a-k & 7a-l) has been rationally designed based on the structure of the lead compound KIST301080, a selective ROS receptor tyrosine kinase inhibitor, in order to study the activity of ROS of this new class of inhibitors. The compounds were synthesized and screened against ROS kinase, where compound 6h showed moderate inhibitory activity with an IC50 value of 6.25 μM. The study emphasized the importance of the acetonitrile group at the pyrazole ring and also the importance of having a hydrogen bond donor on the distal phenyl ring linked to the pyridine moiety.
