1421275-85-5

Basic information

• Product Name: C₂₆H₂₅N₅O₃
• CAS NO: 1421275-85-5
• Molecular Weight: 455.516
• Mol File: 1421275-85-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₆H₂₅N₅O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₆H₂₅N₅O₃(1421275-85-5)
• EPA Substance Registry System: C₂₆H₂₅N₅O₃(1421275-85-5)

Safety Data

• Hazardous Substances Data: 1421275-85-5(Hazardous Substances Data)

Upstream product

• 101251-09-6 (4-acetylaminophenyl)boronic acid 

Relevant articles and documents

Synthesis and biological activity of new 4-(Pyridin-4-yl)-(3-methoxy-5- methylphenyl)- 1H-pyrazoles derivatives as ROS Receptor tyrosine kinase inhibitors

A series of new 4-(pyridin-4-yl)-(3-methoxy-5-methylphenyl)-1H-pyrazoles (6a-k & 7a-l) has been rationally designed based on the structure of the lead compound KIST301080, a selective ROS receptor tyrosine kinase inhibitor, in order to study the activity of ROS of this new class of inhibitors. The compounds were synthesized and screened against ROS kinase, where compound 6h showed moderate inhibitory activity with an IC50 value of 6.25 μM. The study emphasized the importance of the acetonitrile group at the pyrazole ring and also the importance of having a hydrogen bond donor on the distal phenyl ring linked to the pyridine moiety.