1421283-85-3

Basic information

• Product Name: 1-(2,3-dimethylphenyl)-3-(5-nitroisoquinolin-1-yl)urea
• CAS NO: 1421283-85-3
• Molecular Weight: 336.35
• Mol File: 1421283-85-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2,3-dimethylphenyl)-3-(5-nitroisoquinolin-1-yl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,3-dimethylphenyl)-3-(5-nitroisoquinolin-1-yl)urea(1421283-85-3)
• EPA Substance Registry System: 1-(2,3-dimethylphenyl)-3-(5-nitroisoquinolin-1-yl)urea(1421283-85-3)

Safety Data

• Hazardous Substances Data: 1421283-85-3(Hazardous Substances Data)

Upstream product

• 98410-86-7 1-Amino-5-nitroisoquinoline 
• 1591-99-7 1-isocyanato-2,3-dimethylbenzene 
• 58142-97-5 1-chloro-5-nitroisoquinoline 
• 19493-44-8 1-chloroisoquinoline 

Downstream Products

• 1421283-65-9 C₁₈H₁₈N₄O 

Relevant articles and documents

Synthesis and antiproliferative activity of new aminoisoquinolinylurea derivatives against melanoma cell line

A series of new diarylureas possessing aminoisoquinoline scaffold was synthesized, and their in vitro antiproliferative activity against A375P human melanoma cell line was tested. Compounds 1d, 1l, 1n, 1p, 1q, and 1t showed superior potency against A375P to Sorafenib. The highest potency was shown by compound 1p possessing 3,5-bis(trifluoromethyl)phenyl terminal ring with IC50 value of 0.41 μM.