1421284-40-3

Basic information

• Product Name: 1-(3-(2-chlorobenzyloxy)pyridin-2-yl)-3-(3-chlorophenyl)urea
• Synonyms: 1-(3-(2-chlorobenzyloxy)pyridin-2-yl)-3-(3-chlorophenyl)urea
• CAS NO: 1421284-40-3
• Molecular Weight: 388.253
• Mol File: 1421284-40-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(3-(2-chlorobenzyloxy)pyridin-2-yl)-3-(3-chlorophenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-(2-chlorobenzyloxy)pyridin-2-yl)-3-(3-chlorophenyl)urea(1421284-40-3)
• EPA Substance Registry System: 1-(3-(2-chlorobenzyloxy)pyridin-2-yl)-3-(3-chlorophenyl)urea(1421284-40-3)

Safety Data

• Hazardous Substances Data: 1421284-40-3(Hazardous Substances Data)

Upstream product

• 16867-03-1 2-amino-3-hydroxypyridine 
• 611-17-6 1-bromomethyl-2-chlorobenzene 
• 107229-61-8 2-Amino-3-(2-chlorobenzyloxy)pyridine 
• 2909-38-8 m-chlorophenyl isocyanate 
• 853318-45-3 1-(3-chlorophenyl)-3-(3-hydroxypyridin-2-yl)urea 

Relevant articles and documents

Synthesis and evaluation of 2-(3-arylureido)pyridines and 2-(3-arylureido)pyrazines as potential modulators of Aβ-induced mitochondrial dysfunction in Alzheimer's disease

A series of 2-(3-arylureido)pyridines and 2-(3-benzylureido)pyridines were synthesized and evaluated as potential modulators for amyloid beta (Aβ)-induced mitochondrial dysfunction in Alzheimer's disease (AD). The blocking activities of forty one small molecules against Aβ-induced mitochondrial permeability transition pore (mPTP) opening were evaluated by JC-1 assay which measures the change of mitochondrial membrane potential (ΔΨm). The inhibitory activity of twenty five compounds against Aβ-induced mPTP opening was superior to that of the standard cyclosporin A (CsA). Six hit compounds have been identified as likely safe in regards to mitochondrial and cellular safety and subjected to assessment for their protective effect against Aβ-induced deterioration of ATP production and cytotoxicity. Among them, compound 7fb has been identified as a lead compound protecting neuronal cells against 67% of neurocytotoxicity and 43% of suppression of mitochondrial ATP production induced by 5 μM concentrations of Aβ. Using CDocker algorithm, a molecular docking model presented a plausible binding mode for these compounds with cyclophilin D (CypD) receptor as a major component of mPTP. Hence, this report presents compound 7fb as a new nonpeptidyl mPTP blocker which would be promising for further development of Alzheimer's disease (AD) therapeutics.

Pyridyl-urea derivatives as blockers of aβ-induced mPTP opening for alzheimer's disease

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