142132-87-4Relevant academic research and scientific papers
The methylation, oxidation and crystallographic characterization of imidazole derivatives
Vampa,Benvenuti,Severi,Malmusi,Antolini
, p. 227 - 234 (1995)
Compounds 2, 3 and 4 were synthesized and the crystal and molecular structures of 1 and 4 were determined. An hptlc technique for studying the methylation rate of 1 and the oxidation rate of 2 was applied.
Mechanism of the asymmetric sulfoxidation in the esomeprazole process: Effects of the imidazole backbone for the enantioselection
Seenivasaperumal, Muthu,Federsel, Hans-Juergen,Szabo, Kalman J.
, p. 903 - 919 (2009)
The asymmetric sulfoxidation reaction of imidazole-based prochiral sulfides was studied to explore the mechanistic details of the highly efficient esomeprazole process, which is one of the few industrial scale catalytic asymmetric procedures. The syntheti
Comparative study of metal-catalyzed iminations of sulfoxides and sulfides
Mancheno, Olga Garcia,Bolm, Carsten
, p. 6674 - 6681 (2008/03/15)
A comparative study of the imination of sulfur compounds with various metal catalysts in combination with isolated or in situ generated iminoiodinanes (PhI=NR) as nitrogen sources is presented. The influence of the metal catalyst towards the imination of a variety of substituted sulfoxides has been evaluated. Moreover, the effect of the different oxidation states of sulfur on the reactivity and selectivity of the nitrogen transfer redox process in the formation of sulfilimines and sulfoximines was studied. Depending on both the specific metal catalyst as well as the employed nitrene precursor, the sulfide/sulfoxide imination ratio varied in transformations of thianthrene-5-oxide and substituted para-thio phenylsulfoxides.
Biotransformation of organic sulfides. Part 12. Conversion of heterocyclic sulfides to chiral sulfoxides by Helminthosporium sp. NRRL 4671 and Mortierella isabellina ATCC 42613
Holland, Herbert L.,Turner, Carl D.,Andreana, Peter R.,Nguyen, Doan
, p. 463 - 471 (2007/10/03)
The enantioselective oxidation of a series of heterocyclic prochiral sulfides to chiral sulfoxides has been examined using the fungal biocatalysts Helminthosporium species NRRL 4671 and Mortierella isabellina ATCC 42613. Methylthiofuranyl and -thiophenyl
